{"id":30078,"date":"2021-03-16T22:15:19","date_gmt":"2021-03-16T22:15:19","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=30078"},"modified":"2021-04-14T08:03:38","modified_gmt":"2021-04-14T07:03:38","slug":"effects-of-pem-on-markers-of-arterial-stiffness-in-me-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/effects-of-pem-on-markers-of-arterial-stiffness-in-me-cfs\/","title":{"rendered":"Effects of Post-Exertional Malaise on markers of arterial stiffness in individuals with ME\/CFS"},"content":{"rendered":"

Effects of Post-Exertional Malaise on markers of arterial stiffness in individuals with Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome<\/a>, by Joshua Bond, Tessa Nielsen and Lynette Hodges in<\/span> Int J Environ Res Public Health<\/em> 2021 Feb 28;18(5):2366 [doi: 10.3390\/ijerph18052366]<\/h3>\n

 <\/p>\n

Research abstract:<\/strong><\/h3>\n

Background:<\/strong><\/p>\n

\"\"Evidence is emerging that individuals with myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) may suffer from chronic vascular<\/a> dysfunction as a result of illness-related oxidative stress<\/a> and vascular inflammation. The study aimed to examine the impact of maximal-intensity<\/a> aerobic exercise on vascular function 48 and 72 h into recovery.<\/p>\n

Methods: <\/strong><\/p>\n

ME\/CFS (n = 11) with gender and age-matched controls (n = 11) were randomly assigned to either a 48 h or 72 h protocol. Each participant had measures of brachial blood pressure, augmentation index (AIx75, standardized to 75 bpm) and carotid-radial pulse wave velocity (crPWV) taken. This was followed by a maximal incremental cycle exercise test. Resting measures were repeated 48 or 72 h later (depending on group allocation).<\/p>\n

Results: <\/strong><\/p>\n

No significant differences were found when ME\/CFS were directly compared to controls at baseline. During recovery, the 48 h control group experienced a significant 7.2% reduction in AIx75 from baseline measures (p < 0.05), while the matched ME\/CFS experienced no change in AIx75. The 72 h ME\/CFS group experienced a non-significant increase of 1.4% from baseline measures. The 48 h and 72 h ME\/CFS groups both experienced non-significant improvements in crPWV (0.56 ms-1 and 1.55 ms-1, respectively).<\/p>\n

Conclusions: <\/strong><\/p>\n

The findings suggest that those with ME\/CFS may not experience exercise-induced vasodilation<\/a> due to chronic vascular damage, which may be a contributor to the onset of post-exertional malaise (PEM).<\/p>\n

 <\/p>\n

Health Rising:<\/strong> Are stiffened arteries increasing cardiovascular risk in ME\/CFS and Fibromyalgia?<\/a> by Cort Johnson, 6 April 2020<\/p>\n