{"id":30106,"date":"2021-03-15T08:28:46","date_gmt":"2021-03-15T08:28:46","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=30106"},"modified":"2021-03-15T08:28:46","modified_gmt":"2021-03-15T08:28:46","slug":"hypothesis-mechanisms-that-prevent-recovery-in-prolonged-icu-patients-also-underlie-me-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/hypothesis-mechanisms-that-prevent-recovery-in-prolonged-icu-patients-also-underlie-me-cfs\/","title":{"rendered":"Hypothesis: mechanisms that prevent recovery in prolonged ICU patients also underlie ME\/CFS"},"content":{"rendered":"<h3><a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2021.628029\/full\" target=\"_blank\" rel=\"noopener\">Hypothesis: mechanisms that prevent recovery in prolonged ICU patients also underlie Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS)<\/a>, by Dominic Stanculescu,\u00a0 Lars Larsson and Jonas Bergquist <span style=\"text-decoration: underline;\">in<\/span> <em>Frontiers in Medicine<\/em> (2021) 8(41) [doi: 10.3389\/fmed.2021.628029] (This article is part of the research topic: Current Insights into Complex Post-Infection Fatigue Syndromes with Unknown Aetiology: the Case of Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome and Beyond)<\/h3>\n<p>&nbsp;<\/p>\n<h3><strong>Article abstract:<\/strong><\/h3>\n<p>Here the hypothesis is advanced that maladaptive mechanisms that prevent recovery in some intensive care unit (ICU) patients may also underlie Myalgic encephalomyelitis\/ chronic fatigue syndrome (ME\/CFS).<\/p>\n<p>Specifically, these mechanisms are: (a) suppression of the pituitary gland&#8217;s pulsatile secretion of tropic hormones, and (b) a \u201cvicious circle\u201d between inflammation, oxidative and nitrosative stress (O&amp;NS), and low thyroid hormone function.<\/p>\n<p><img data-recalc-dims=\"1\" decoding=\"async\" class=\"aligncenter size-full wp-image-30121 lazyload\" data-src=\"https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2021\/03\/critical-illness-model.jpg?resize=880%2C523&#038;ssl=1\" alt=\"\" width=\"880\" height=\"523\" data-srcset=\"https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2021\/03\/critical-illness-model.jpg?w=957&amp;ssl=1 957w, https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2021\/03\/critical-illness-model.jpg?resize=300%2C178&amp;ssl=1 300w, https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2021\/03\/critical-illness-model.jpg?resize=150%2C89&amp;ssl=1 150w, https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2021\/03\/critical-illness-model.jpg?resize=768%2C457&amp;ssl=1 768w\" data-sizes=\"(max-width: 880px) 100vw, 880px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 880px; --smush-placeholder-aspect-ratio: 880\/523;\" \/><\/p>\n<p>This hypothesis should be investigated through collaborative research projects.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hypothesis: mechanisms that prevent recovery in prolonged ICU patients also underlie Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS), by Dominic Stanculescu,\u00a0 Lars Larsson and Jonas Bergquist in Frontiers in Medicine (2021) 8(41) [doi: 10.3389\/fmed.2021.628029] (This article is part of the research topic: &hellip; <a href=\"https:\/\/wames.org.uk\/cms-english\/hypothesis-mechanisms-that-prevent-recovery-in-prolonged-icu-patients-also-underlie-me-cfs\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[6652,6653,447,6654,6651,306,2231,2232,3985,3239],"class_list":["post-30106","post","type-post","status-publish","format-standard","hentry","category-news","tag-dominic-stanculescu","tag-icu","tag-inflammation","tag-intensive-care-unit","tag-lars-larsson","tag-oxidative-stress","tag-pifs","tag-post-infectious-fatigue-syndrome","tag-prof-jonas-bergquist","tag-thyroid"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-7PA","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/30106","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=30106"}],"version-history":[{"count":2,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/30106\/revisions"}],"predecessor-version":[{"id":30122,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/30106\/revisions\/30122"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=30106"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=30106"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=30106"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}