{"id":30157,"date":"2021-03-19T08:15:27","date_gmt":"2021-03-19T08:15:27","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=30157"},"modified":"2021-07-08T23:17:50","modified_gmt":"2021-07-08T22:17:50","slug":"covid-19-me-cfs-a-methyl-group-assault","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/covid-19-me-cfs-a-methyl-group-assault\/","title":{"rendered":"COVID-19 (& ME\/CFS?): a methyl-group assault?"},"content":{"rendered":"

COVID-19: A methyl-group assault? <\/a>by Andrew McCaddon, Bj\u00f6rn Regland in<\/span> Medical Hypotheses <\/em>Vol 149, Apr 2021, 110543 [ doi.org\/10.1016\/j.mehy.2021.110543]<\/h3>\n

 <\/p>\n

Research abstract:<\/strong><\/h3>\n

The socio-economic implications of COVID-19 are devastating. Considerable morbidity is attributed to \u2018long-COVID\u2019 \u2013 an increasingly recognized complication of infection. Its diverse symptoms are reminiscent of vitamin B12 deficiency, a condition in which methylation status<\/a> is compromised.<\/p>\n

\"\"We suggest why SARS-CoV-2 infection likely leads to increased methyl-group requirements and other disturbances of one-carbon metabolism<\/a>. We propose these might explain the varied symptoms of long-COVID. Our suggested mechanism\u00a0might also apply to similar conditions such as myalgic encephalomyelitis\/chronic fatigue syndrome<\/strong>.<\/p>\n

The hypothesis is evaluable by detailed determination of vitamin B12\u00a0and\u00a0folate<\/a> status, including serum formate as well as homocysteine and methylmalonic acid, and correlation with viral and host RNA methylation and symptomatology. If confirmed, methyl-group support [supplementation] should prove beneficial in such individuals.<\/p>\n

Conclusion<\/strong><\/h3>\n

We suggest that SARS-CoV-2 induces an increased demand for methyl-groups<\/a> whilst simultaneously impairing their supply due to viral-induced oxidative stress<\/a>.<\/p>\n

The biochemical implications of our hypothesis might explain the diverse symptoms experienced by patients with long-COVID and, if confirmed, suggests possible approaches to treatment.<\/p>\n

It would be ironic if the socio-economic devastation of COVID-19, by intensifying world-wide research in a viral pandemic, leads to valuable insights into other conditions such as ME\/CFS,<\/strong> as well as providing additional clues to the aetiology of memory disorders and\u00a0dementia, including Alzheimer\u2019s disease.<\/p>\n

Image by\u00a0mcmurryjulie<\/a>\u00a0from\u00a0Pixabay<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

COVID-19: A methyl-group assault? by Andrew McCaddon, Bj\u00f6rn Regland in Medical Hypotheses Vol 149, Apr 2021, 110543 [ doi.org\/10.1016\/j.mehy.2021.110543]   Research abstract: The socio-economic implications of COVID-19 are devastating. Considerable morbidity is attributed to \u2018long-COVID\u2019 \u2013 an increasingly recognized complication … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[6658,6657,6660,1261,6659,306,1677],"class_list":["post-30157","post","type-post","status-publish","format-standard","hentry","category-news","tag-andrew-mccaddon","tag-bjorn-regland","tag-folate","tag-metabolism","tag-methylation-status","tag-oxidative-stress","tag-vitamin-b12"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-7Qp","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/30157","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=30157"}],"version-history":[{"count":4,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/30157\/revisions"}],"predecessor-version":[{"id":30169,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/30157\/revisions\/30169"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=30157"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=30157"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=30157"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}