{"id":30485,"date":"2021-04-13T08:02:35","date_gmt":"2021-04-13T07:02:35","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=30485"},"modified":"2021-04-13T08:12:35","modified_gmt":"2021-04-13T07:12:35","slug":"insights-into-metabolite-diagnostic-biomarkers-for-me-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/insights-into-metabolite-diagnostic-biomarkers-for-me-cfs\/","title":{"rendered":"Insights into metabolite diagnostic biomarkers for ME\/CFS"},"content":{"rendered":"

Insights into metabolite diagnostic biomarkers for Myalgic Encephalomyelitis\/ Chronic Fatigue Syndrome<\/a>, by Emi Yamano, Yasuyoshi Watanabe and Yosky Kataoka in<\/span> Int. J. Mol. Sci<\/em>. 2021, 22(7), 3423; [doi.org\/10.3390\/ijms22073423] 26 March 2021
\n(This article belongs to the Special Issue\u00a0Environmental Sensitivity Illnesses: Mechanisms and Molecular Signatures 2.0)<\/h3>\n

 <\/p>\n

Review abstract:<\/strong><\/h3>\n

Myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) is a persistent and unexplained pathological state characterized by exertional and severely debilitating fatigue, with\/without infectious or neuropsychiatric symptoms, and with a minimum duration of 6 consecutive months.<\/p>\n

Its pathogenesis<\/a> is not fully understood. There are no firmly established diagnostic biomarkers<\/a> or treatment, due to incomplete understanding of the etiology<\/a> of ME\/CFS and diagnostic uncertainty.<\/p>\n

Establishing a biomarker for the objective diagnosis is urgently needed to treat a lot of patients. Recently, research on ME\/CFS using metabolome<\/a> analysis methods has been increasing. Here, we overview recent findings concerning the metabolic features in patients with ME\/CFS and the animal models which contribute to the development of diagnostic biomarkers for ME\/CFS and its treatment. In addition, we discuss future perspectives of studies on ME\/CFS.<\/p>\n

Table 2. Summary of major biochemical pathways with significant metabolites across patients with ME\/CFS:<\/em><\/p>\n

\"Table<\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

4. Conclusions<\/strong>
\nCommon metabolic fluctuations were observed in fatigued animal models and human patients with ME\/CFS and these findings could contribute to the elucidation of the pathophysiology of ME\/CFS. Biomarker research, to distinguish between patients with ME\/CFS and healthy individuals, is still evolving.<\/p>\n

In previous studies, reactive oxygen metabolite-derived compounds (d-ROMs) [54] in the blood, exosomes and inclusion proteins\/micro RNAs [5], monocyte number, and lipoprotein profiles have been reported to be informative markers for discriminating patients with ME\/CFS from healthy controls [55]. Furthermore, inflammation and immune system activation have been suggested by many previous studies to be the root causes of ME\/CFS, and the results from many such studies have shown elevation of cytokines and lymphokines in plasma [56].<\/p>\n

Using positron emission tomography (PET), neuroinflammation was detected in wide-spread brain regions of patients with ME\/CFS, which was associated with the severity of the specific neuro-psychologic symptoms [57].<\/p>\n

We believe that in future, it will be possible to establish highly precise objective diagnostic biomarkers for ME\/CFS, exhibiting diverse pathologies<\/strong> through the implementation of research that would integrate metabolomic markers reflecting the specific metabolism underlying the pathophysiology of fatigue with highly precise in vivo biomarkers.<\/p>\n","protected":false},"excerpt":{"rendered":"

Insights into metabolite diagnostic biomarkers for Myalgic Encephalomyelitis\/ Chronic Fatigue Syndrome, by Emi Yamano, Yasuyoshi Watanabe and Yosky Kataoka in Int. J. Mol. Sci. 2021, 22(7), 3423; [doi.org\/10.3390\/ijms22073423] 26 March 2021 (This article belongs to the Special Issue\u00a0Environmental Sensitivity Illnesses: … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[4170,93,6679,1262,759,3169],"class_list":["post-30485","post","type-post","status-publish","format-standard","hentry","category-news","tag-biomarker","tag-diagnosis","tag-emi-yamano","tag-metabolomics","tag-yasuyoshi-watanabe","tag-yosky-kataoka"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-7VH","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/30485","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=30485"}],"version-history":[{"count":6,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/30485\/revisions"}],"predecessor-version":[{"id":30507,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/30485\/revisions\/30507"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=30485"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=30485"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=30485"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}