{"id":31904,"date":"2021-08-25T08:41:04","date_gmt":"2021-08-25T07:41:04","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=31904"},"modified":"2021-08-25T08:41:04","modified_gmt":"2021-08-25T07:41:04","slug":"biomarker-research-the-case-for-hyperbaric-oxygen-therapy-in-cfs-biomarker-identification","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/biomarker-research-the-case-for-hyperbaric-oxygen-therapy-in-cfs-biomarker-identification\/","title":{"rendered":"Biomarker research: The case for hyperbaric oxygen therapy in CFS biomarker identification"},"content":{"rendered":"

Chronic fatigue syndrome and epigenetics: the case for hyperbaric<\/a>
\noxygen therapy in biomarker identification, by Rajit J Shah in<\/span> J\u00a0Pulmonol Respir Res<\/em>. 2021; 5: 027-030. [DOI: 10.29328\/journal.jprr.1001020]<\/h3>\n

 <\/p>\n

Review abstract:<\/strong><\/h3>\n

Chronic fatigue syndrome (CFS) is a poorly-understood respiratory condition that affects millions of individuals. Hyperbaric oxygen therapy<\/a> (HBOT) is a treatment option being considered to address CFS as it is suggested to combat fatigue and increase oxygenation.<\/p>\n

\"\"<\/p>\n

HBOT provides two opportunities in advancing research of CFS:\u00a0it may provide data on symptom amelioration and be utilized in the search for a biomarker<\/a>.<\/p>\n

By either identifying biomarkers before using HBOT to compare epigenomes of patients before and after treatment or using HBOT to find epigenetic<\/a> discrepancies between patients with and without treatment, matching epigenetic regulation with symptom amelioration may significantly advance the understanding of the etiology<\/a> and treatment mechanism for CFS.<\/p>\n

EPAS1\/HIF-2\u03b1<\/a> is a leading candidate for an epigenetic biomarker as it responds differentially to hypoxic<\/a> and normoxic<\/a> conditions, which degrades more slowly in hypoxic conditions. Epigenetic regulation of EPAS1\/HIF-2\u03b1 in
\nsuch differential conditions may be explored in HBOT experiments.<\/p>\n

In addition to HBOT as a promising treatment option for CFS symptoms, it may aid the identification of biomarkers in CFS. Further research into both outcomes is strongly encouraged.<\/p>\n","protected":false},"excerpt":{"rendered":"

Chronic fatigue syndrome and epigenetics: the case for hyperbaric oxygen therapy in biomarker identification, by Rajit J Shah in J\u00a0Pulmonol Respir Res. 2021; 5: 027-030. [DOI: 10.29328\/journal.jprr.1001020]   Review abstract: Chronic fatigue syndrome (CFS) is a poorly-understood respiratory condition that … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[4170,6979,6980,6981],"class_list":["post-31904","post","type-post","status-publish","format-standard","hentry","category-news","tag-biomarker","tag-epas1-hif-2","tag-hyperbaric-oxygen-therapy","tag-rajit-j-shah"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-8iA","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/31904","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=31904"}],"version-history":[{"count":6,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/31904\/revisions"}],"predecessor-version":[{"id":32536,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/31904\/revisions\/32536"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=31904"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=31904"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=31904"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}