{"id":32165,"date":"2021-08-02T08:41:02","date_gmt":"2021-08-02T07:41:02","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=32165"},"modified":"2021-08-02T08:41:48","modified_gmt":"2021-08-02T07:41:48","slug":"research-effect-of-dietary-coenzyme-q10-plus-nadh-supplementation-on-fatigue-perception-health-related-quality-of-life-in-me-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/research-effect-of-dietary-coenzyme-q10-plus-nadh-supplementation-on-fatigue-perception-health-related-quality-of-life-in-me-cfs\/","title":{"rendered":"Research: Effect of dietary Coenzyme Q10 plus NADH supplementation on fatigue perception & health-related quality of life in ME\/CFS"},"content":{"rendered":"

Effect of dietary Coenzyme Q10 plus NADH supplementation on fatigue perception and health-related quality of life in individuals with Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome: a prospective, randomized, double-blind, placebo-controlled trial<\/a>, by\u00a0 Jes\u00fas Castro-Marrero, Maria Jose Segundo, Marcos Lacasa, Alba Martinez-Martinez, Ramon Sanmartin Senta\u00f1es and Jose Alegre-Martin in<\/span> Nutrients<\/em> 2021, 13(8), 2658; [doi.org\/10.3390\/nu13082658] 30 July 2021 (This article belongs to the Special Issue\u00a0Dietary Supplements in Cardiovascular and Metabolic Diseases)<\/h3>\n

 <\/p>\n

Research abstract:<\/strong><\/h3>\n

Myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) is a complex, multisystem, and profoundly debilitating neuroimmune disease, probably of post-viral multifactorial etiology. Unfortunately, no accurate diagnostic or laboratory tests have been established, nor are any universally effective approved drugs currently available for its treatment.<\/p>\n

\"\"This study aimed to examine whether oral coenzyme Q10 and NADH (reduced form of nicotinamide adenine dinucleotide) co-supplementation could improve perceived fatigue, unrefreshing sleep, and health-related quality of life in ME\/CFS patients.<\/p>\n

A 12-week prospective, randomized, double-blind, placebo-controlled trial was conducted in 207 patients with ME\/CFS, who were randomly allocated to one of two groups to receive either 200 mg of CoQ10 and 20 mg of NADH (n = 104) or matching placebo (n = 103) once daily. Endpoints were simultaneously evaluated at baseline, and then reassessed at 4- and 8-week treatment visits and four weeks after treatment cessation, using validated patient-reported outcome measures.<\/p>\n

A significant reduction in cognitive fatigue perception and overall FIS-40<\/a> score (p < 0.001 and p = 0.022, respectively) and an improvement in HRQoL (health-related quality of life (SF-36)) (p < 0.05) from baseline were observed within the experimental group over time. Statistically significant differences were also shown for sleep duration at 4 weeks and habitual sleep efficiency at 8 weeks in follow-up visits from baseline within the experimental group (p = 0.018 and p = 0.038, respectively).<\/p>\n

Overall, these findings support the use of CoQ10 plus NADH supplementation as a potentially safe therapeutic option for reducing perceived cognitive fatigue and improving the health-related quality of life in ME\/CFS patients.<\/p>\n

Future interventions are needed to corroborate these clinical benefits and also explore the underlying pathomechanisms of CoQ10 and NADH administration in ME\/CFS.<\/p>\n

5. Conclusions<\/strong><\/h3>\n

To the best of our knowledge, this is the first study to assess the effects of oral CoQ10 plus NADH supplementation administered to a substantial number of ME\/CFS patients (n = 207). Our findings suggest that, over a two-month period, this combination is potentially effective in reducing cognitive fatigue (also known as \u201cbrain fog\u201d) and overall fatigue perception, thus improving HRQoL in ME\/CFS.<\/p>\n

The study shows that CoQ10 and NADH can be safely co-administered to ME\/CFS patients and are generally well-tolerated at the dosages indicated. A therapeutic effect was also demonstrated on sleep quality within the experimental group.<\/p>\n

Long-term RCTs in larger ME\/CFS cohorts should now be performed to confirm the effectiveness of CoQ10 and NADH co-supplementation in treating the hallmark symptom of post-exertional malaise using two-day consecutive cardiopulmonary exercise testing (2-day CPET).<\/p>\n","protected":false},"excerpt":{"rendered":"

Effect of dietary Coenzyme Q10 plus NADH supplementation on fatigue perception and health-related quality of life in individuals with Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome: a prospective, randomized, double-blind, placebo-controlled trial, by\u00a0 Jes\u00fas Castro-Marrero, Maria Jose Segundo, Marcos Lacasa, Alba Martinez-Martinez, Ramon … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[4290,590,9,716,6925,6924,6923,1872,1871,4284,5453,6920,6921,1307,6922,1074,6919],"class_list":["post-32165","post","type-post","status-publish","format-standard","hentry","category-news","tag-alba-martinez-martinez","tag-brain-fog","tag-chronic-fatigue","tag-coenzyme-q10","tag-cognitive-fatigue","tag-fatigue-impact-scale-40","tag-fis-40","tag-health-related-quality-of-life","tag-hrqol","tag-jesus-castro-marrero","tag-jose-alegre-martin","tag-marcos-lacasa","tag-maria-jose-segundo","tag-nadh","tag-nonrestorative-sleep","tag-quality-of-life","tag-ramon-sanmartin-sentanes"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-8mN","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/32165","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=32165"}],"version-history":[{"count":3,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/32165\/revisions"}],"predecessor-version":[{"id":32176,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/32165\/revisions\/32176"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=32165"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=32165"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=32165"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}