{"id":32333,"date":"2021-08-20T08:47:48","date_gmt":"2021-08-20T07:47:48","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=32333"},"modified":"2021-08-20T08:47:48","modified_gmt":"2021-08-20T07:47:48","slug":"research-diffusion-tensor-imaging-mri-reveals-neuronal-microstructural-changes-in-me-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/research-diffusion-tensor-imaging-mri-reveals-neuronal-microstructural-changes-in-me-cfs\/","title":{"rendered":"Research: Diffusion tensor imaging (MRI) reveals neuronal microstructural changes in ME\/CFS"},"content":{"rendered":"

Diffusion tensor imaging reveals neuronal microstructural changes in Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome<\/a>, by\u00a0Kiran Thapaliya, Sonya Marshall-Gradisnik, Don Staines, Leighton Barnden in<\/span> European Journal of Neuroscience<\/em>, August 6, 2021 [doi\/10.1111\/ejn.15413]<\/h3>\n

 <\/p>\n

Research abstract:<\/strong><\/h3>\n
\n

Myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) patients suffer from a variety of physical and neurological complaints indicating the central nervous system plays a role in ME\/CFS pathophysiology.<\/p>\n

Diffusion tensor imaging<\/a> (DTI) has been used to study microstructural changes in neurodegenerative diseases. In this study, we evaluated DTI parameters to investigate microstructural abnormalities in ME\/CFS patients.<\/p>\n

We estimated DTI parameters in 25 ME\/CFS patients who met Fukuda criteria<\/a> (ME\/CFSFukuda<\/sub>), 18 ME\/CFS patients who met International Consensus Criteria<\/a> (ICC) (ME\/CFSICC<\/sub>) only and 26 healthy control (HC) subjects. In addition to voxel-based DTI-parameter group comparisons, we performed voxel-based<\/a> DTI-parameter interaction-with-group regressions with clinical and autonomic measures to test for abnormal regressions.<\/p>\n

\"\"

Results of voxel-based group comparisons of AD, MD and MO. (a) decreased AD in ME\/CFS (ICC).<\/p><\/div>\n

Group comparisons between ME\/CFSICC<\/sub>\u00a0and HC detected significant clusters (a) with decreased axial diffusivity (p<\/i>\u2009=\u2009.001) and mean diffusivity (p<\/i>\u2009=\u2009.01) in the descending cortico-cerebellar tract in the midbrain and pons and (b) with increased transverse diffusivity in the medulla. The mode of anisotropy was significantly decreased (p<\/i>\u2009=\u2009.001) in a cluster in the superior longitudinal fasciculus region.<\/p>\n

Voxel-based group comparisons between ME\/CFSFukuda<\/sub>\u00a0and HC did not detect significant clusters. For ME\/CFSICC<\/sub>\u00a0and HC, DTI parameter interaction-with-group regressions were abnormal for the clinical measures of information processing score, SF36 physical, sleep disturbance score and respiration rate in both grey and white matter regions.<\/p>\n

Our study demonstrated that DTI parameters are sensitive to microstructural changes in ME\/CFSICC<\/sub>\u00a0and could potentially act as an imaging biomarker of abnormal pathophysiology in ME\/CFS. The study also shows that strict case definitions are essential in investigation of the pathophysiology of ME\/CFS.<\/p>\n<\/div>\n

Excerpt from Conclusion:<\/strong><\/h3>\n

Our DTI study detected axonal microstructural abnormalities in ME\/CFS patients. The group analysis using a voxel-based method detected differences in diffusion metrics in ascending and descending tracts in the medulla, pons and midbrain of the brainstem in ME\/CFS patients, but only for those meeting ICC criteria.<\/p>\n

This demonstrated the importance of strict case definitions for ME\/CFS. Our DTI parameter interaction-with-group regressions with clinical measures showed involvement of multiple brain regions. These novel analyses can contribute to understanding the pathophysiology of ME\/CFS patients. Brainstem abnormality may be an imaging diagnostic marker for ME\/CFS.<\/p>\n","protected":false},"excerpt":{"rendered":"

Diffusion tensor imaging reveals neuronal microstructural changes in Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome, by\u00a0Kiran Thapaliya, Sonya Marshall-Gradisnik, Don Staines, Leighton Barnden in European Journal of Neuroscience, August 6, 2021 [doi\/10.1111\/ejn.15413]   Research abstract: Myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) patients suffer from … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[2572,107,6976,3495,1249,1517,778,5872,1037,2676,3873],"class_list":["post-32333","post","type-post","status-publish","format-standard","hentry","category-news","tag-brainstem","tag-diagnostic-criteria","tag-diffusion-tensor-imaging","tag-dr-leighton-barnden","tag-dr-sonya-marshall-gradisnik","tag-fukuda","tag-international-consensus-criteria","tag-kiran-thapaliya","tag-mri","tag-prof-donald-staines","tag-voxel-based-morphometry"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-8pv","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/32333","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=32333"}],"version-history":[{"count":4,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/32333\/revisions"}],"predecessor-version":[{"id":32488,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/32333\/revisions\/32488"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=32333"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=32333"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=32333"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}