{"id":32456,"date":"2021-08-18T08:54:06","date_gmt":"2021-08-18T07:54:06","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=32456"},"modified":"2021-09-02T21:43:34","modified_gmt":"2021-09-02T20:43:34","slug":"research-review-redox-imbalance-links-covid-19-me-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/research-review-redox-imbalance-links-covid-19-me-cfs\/","title":{"rendered":"Research review: Redox imbalance links COVID-19 & ME\/CFS"},"content":{"rendered":"

Redox imbalance links COVID-19 and myalgic encephalomyelitis\/chronic fatigue syndrome<\/a>, by Bindu D Paul, Marian D Lemle, Anthony L Komaroff, Solomon H Snyder in<\/span> PNAS<\/em> August 24,\u00a0 2021 118 (34); [doi.org\/10.1073\/pnas.2024358118]<\/h3>\n

 <\/p>\n

Review abstract:<\/strong><\/h3>\n

Although most patients recover from acute COVID-19, some experience postacute sequelae of severe acute respiratory syndrome coronavirus 2 infection (PASC). One subgroup of PASC is a syndrome called \u201clong COVID-19,\u201d reminiscent of myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS).<\/p>\n

ME\/CFS is a debilitating condition, often triggered by viral and bacterial infections, leading to years-long debilitating symptoms including profound fatigue, postexertional malaise, unrefreshing sleep, cognitive deficits, and orthostatic intolerance. Some are skeptical that either ME\/CFS or long COVID-19 involves underlying biological abnormalities.<\/p>\n

However, in this review, we we summarize the evidence that people with acute COVID-19 and with ME\/CFS have biological abnormalities including redox imbalance, systemic inflammation and neuroinflammation, an impaired ability to generate adenosine triphosphate, and a general hypometabolic state.<\/p>\n

 <\/p>\n

Redox biology refers to low levels of ROS<\/a> that activate signaling pathways to initiate biological processes while oxidative stress denotes high levels of ROS that incur damage to DNA, protein or lipids. Schieber & Chandel<\/a><\/p><\/blockquote>\n

These phenomena have not yet been well studied in people with long COVID-19, and each of them has been reported in other diseases as well, particularly neurological diseases.<\/p>\n

\"\"<\/p>\n

We also examine the bidirectional relationship between redox imbalance, inflammation, energy metabolic deficits, and a hypometabolic state. We speculate as to what may be causing these abnormalities. Thus, understanding the molecular underpinnings of both PASC and ME\/CFS may lead to the development of novel therapeutics.<\/p>\n

 <\/p>\n

Comments:<\/strong><\/h3>\n

News-medical.net:<\/strong> Review highlights similarities between long COVID and chronic fatigue syndrome<\/a>, by Emily Henderson\u00a0 \u00a026 Aug 2021<\/p>\n

John Hopkins<\/strong>: For many, long COVID looks a lot like chronic fatigue<\/a> \u00a025 Aug 2021<\/p>\n

Health Rising:<\/strong> Could a Free Radical Explosion Be Causing ME\/CFS and Long COVID?<\/a>, by Cort Johnson\u00a0 \u00a021 Aug 2021<\/p>\n

Solve ME:<\/strong> Newly published research connects ME\/CFS and COVID-19<\/a>,\u00a0 26 Aug 2021<\/p>\n

A comprehensive review of ME\/CFS and Long Covid research published this week suggests that symptoms of both may be caused by redox imbalance, which is linked to inflammation and reduction of cellular energy production. [Redox imbalance occurs when oxidants and antioxidants in a cell are in a state of disequilibrium, which can lead to cell death and contribute to disease development.]<\/p>\n","protected":false},"excerpt":{"rendered":"

Redox imbalance links COVID-19 and myalgic encephalomyelitis\/chronic fatigue syndrome, by Bindu D Paul, Marian D Lemle, Anthony L Komaroff, Solomon H Snyder in PNAS August 24,\u00a0 2021 118 (34); [doi.org\/10.1073\/pnas.2024358118]   Review abstract: Although most patients recover from acute COVID-19, … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[6974,6972,5684,6196,6973,168,705,559,6861,6971,801,4811,6975],"class_list":["post-32456","post","type-post","status-publish","format-standard","hentry","category-news","tag-anthony-l-komaroff","tag-bindu-d-paul","tag-covid-19","tag-long-covid","tag-marian-d-lemle","tag-mitochondrial-dysfunction","tag-neuroinflammation","tag-oxidative-and-nitrosative-stress","tag-pasc","tag-postacute-sequelae-of-severe-acute-respiratory-syndrome-coronavirus-2-infection","tag-prof-anthony-komaroff","tag-redox-imbalance","tag-solomon-h-snyder"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-8ru","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/32456","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=32456"}],"version-history":[{"count":6,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/32456\/revisions"}],"predecessor-version":[{"id":32725,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/32456\/revisions\/32725"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=32456"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=32456"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=32456"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}