{"id":33106,"date":"2021-10-14T08:00:26","date_gmt":"2021-10-14T07:00:26","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=33106"},"modified":"2021-10-14T08:00:26","modified_gmt":"2021-10-14T07:00:26","slug":"research-neurochemical-abnormalities-in-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/research-neurochemical-abnormalities-in-cfs\/","title":{"rendered":"Research: Neurochemical abnormalities in CFS"},"content":{"rendered":"

Neurochemical abnormalities in chronic fatigue syndrome: a pilot magnetic resonance spectroscopy study at 7 Tesla<\/a>, by Beata R Godlewska, Stephen Williams, Uzay E Emir, Chi Chen, Ann L Sharpley, Ana Jorge Goncalves, Monique I Andersson, William Clarke, Brian Angus, Philip J Cowen in<\/span>\u00a0Psychopharmacology<\/em>, October 5, 2021<\/h3>\n

 <\/p>\n

Research abstract:\u00a0<\/strong><\/h3>\n

Rationale<\/strong><\/p>\n

Chronic fatigue syndrome (CFS) is a common and burdensome illness with a poorly understood pathophysiology, though many of the characteristic symptoms are likely to be of brain origin. The use of high-field proton magnetic resonance spectroscopy<\/a> (MRS) enables the detection of a range of brain neurochemicals relevant to aetiological processes that have been linked to CFS, for example, oxidative stress and mitochondrial dysfunction.<\/p>\n

Methods<\/strong><\/p>\n

We studied 22 CFS patients and 13 healthy controls who underwent MRS scanning at 7 T with a voxel placed in the anterior cingulate cortex.\u00a0Neurometabolite<\/a> concentrations were calculated using the unsuppressed water signal<\/a> as a reference.<\/p>\n

\"\"Results<\/strong><\/p>\n

Compared to controls, CFS patients had lowered levels of glutathione<\/a>, total creatine<\/a> and myo-inositol<\/a> in anterior cingulate cortex<\/a>. However, when using N-acetylaspartate<\/a> as a reference metabolite, only myo-inositol levels continued to be significantly lower in CFS participants.<\/p>\n

Conclusions<\/strong><\/p>\n

The changes in glutathione and creatine are consistent with the presence of oxidative and energetic stress in CFS patients and are potentially remediable by nutritional intervention. A reduction in myo-inositol would be consistent with glial<\/a> dysfunction. However, the relationship of the neurochemical abnormalities to the causation of CFS remains to be established, and the current findings require prospective replication in a larger sample.<\/p>\n","protected":false},"excerpt":{"rendered":"

Neurochemical abnormalities in chronic fatigue syndrome: a pilot magnetic resonance spectroscopy study at 7 Tesla, by Beata R Godlewska, Stephen Williams, Uzay E Emir, Chi Chen, Ann L Sharpley, Ana Jorge Goncalves, Monique I Andersson, William Clarke, Brian Angus, Philip … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[7082,7081,7076,7078,7085,4072,3541,4971,3476,7083,7077,7086,7079,7080,7084],"class_list":["post-33106","post","type-post","status-publish","format-standard","hentry","category-news","tag-ana-jorge-goncalves","tag-ann-l-sharpley","tag-anterior-cingulate-cortex","tag-beata-r-godlewska","tag-brian-angus","tag-chi-chen","tag-cortical-glutathione","tag-creatine-kinase","tag-magnetic-resonance-spectroscopy","tag-monique-i-andersson","tag-myo-inositol","tag-philip-j-cowen","tag-stephen-williams","tag-uzay-e-emir","tag-william-clarke"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-8BY","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/33106","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=33106"}],"version-history":[{"count":2,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/33106\/revisions"}],"predecessor-version":[{"id":33179,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/33106\/revisions\/33179"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=33106"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=33106"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=33106"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}