{"id":33207,"date":"2021-10-26T08:38:29","date_gmt":"2021-10-26T07:38:29","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=33207"},"modified":"2021-10-26T08:39:04","modified_gmt":"2021-10-26T07:39:04","slug":"research-can-connectivity-predicts-symptoms-in-me-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/research-can-connectivity-predicts-symptoms-in-me-cfs\/","title":{"rendered":"Research: CAN connectivity predicts symptoms in ME\/CFS"},"content":{"rendered":"<h3><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0167876021009004?via%3Dihub\" target=\"_blank\" rel=\"noopener\">Cortical autonomic network connectivity predicts symptoms in myalgic encephalomyelitis\/ chronic fatigue syndrome (ME\/CFS)<\/a>, by Mark A Zinn, Leonard A Jason <span style=\"text-decoration: underline;\">in<\/span> <em>International Journal of Psychophysiology<\/em> Vol 170, Dec 2021, Pages 89-101 [doi.org\/10.1016\/j.ijpsycho.2021.10.004]<\/h3>\n<p>&nbsp;<\/p>\n<h3><strong>Highlights<\/strong><\/h3>\n<ul>\n<li>The findings of this study contribute to the understanding of unexplained symptoms in patients with ME\/CFS.<\/li>\n<li>Graph theoretical analysis revealed topological differences between groups that were associated with patient symptoms.<\/li>\n<li>Results suggest that cortical dysregulation with this network may serve as a therapeutic target for patients.<\/li>\n<\/ul>\n<h3><strong>Research abstract:<\/strong><\/h3>\n<p>Myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) represents a significant public health challenge given the presence of many unexplained patient symptoms. Research has shown that many features in ME\/CFS may result from a dysfunctional <a href=\"https:\/\/www.msdmanuals.com\/en-gb\/home\/brain,-spinal-cord,-and-nerve-disorders\/autonomic-nervous-system-disorders\/overview-of-the-autonomic-nervous-system\" target=\"_blank\" rel=\"noopener\">autonomic nervous system<\/a> (ANS).<\/p>\n<p><img data-recalc-dims=\"1\" decoding=\"async\" class=\"alignright size-medium wp-image-33237 lazyload\" data-src=\"https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2021\/10\/EEG.jpg?resize=300%2C285&#038;ssl=1\" alt=\"\" width=\"300\" height=\"285\" data-srcset=\"https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2021\/10\/EEG.jpg?resize=300%2C285&amp;ssl=1 300w, https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2021\/10\/EEG.jpg?resize=150%2C143&amp;ssl=1 150w, https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2021\/10\/EEG.jpg?w=627&amp;ssl=1 627w\" data-sizes=\"(max-width: 300px) 100vw, 300px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 300px; --smush-placeholder-aspect-ratio: 300\/285;\" \/>We explored the role of the cortical autonomic network (CAN) involved in higher-order control of ANS functioning in 34 patients with ME\/CFS and 34 healthy controls under task-free conditions. All participants underwent resting-state <a href=\"https:\/\/qeegsupport.com\/what-is-qeeg-or-brain-mapping\/#:~:text=Quantitative%20Electroencephalography%20(qEEG)%20is%20a,applications%20%E2%80%9CWavelet%E2%80%9D%20analysis).\" target=\"_blank\" rel=\"noopener\">quantitative electroencephalographic<\/a> (qEEG) scalp recordings during an eyes-closed condition.<\/p>\n<p>Source analysis was performed using exact low-resolution electromagnetic tomography (eLORETA), and lagged coherence was used to estimate intrinsic functional connectivity between each node across 7 frequency bands: delta (1\u20133 Hz), theta (4\u20137 Hz), alpha-1 (8\u201310 Hz), alpha-2 (10\u201312 Hz), beta-1 (13\u201318 Hz), beta-2 (19\u201321 Hz), and beta-3 (22\u201330 Hz).<\/p>\n<p>Symptom ratings were measured using the <a href=\"https:\/\/me-pedia.org\/wiki\/DePaul_Symptom_Questionnaire\" target=\"_blank\" rel=\"noopener\">DePaul Symptom Questionnaire<\/a> and the <a href=\"https:\/\/www.physio-pedia.com\/36-Item_Short_Form_Survey_(SF-36)\" target=\"_blank\" rel=\"noopener\">Short Form (SF-36)<\/a> health survey.<\/p>\n<p><a href=\"https:\/\/en.wikipedia.org\/wiki\/Graph_theory\" target=\"_blank\" rel=\"noopener\">Graph theoretical analysis<\/a> of weighted, undirected connections revealed significant group differences in baseline CAN organization. Regression results showed that <a href=\"https:\/\/www.psychguides.com\/neurological-disorders\/cognitive\/\" target=\"_blank\" rel=\"noopener\">cognitive<\/a>, <a href=\"https:\/\/www.healthline.com\/health\/affective-disorders\" target=\"_blank\" rel=\"noopener\">affective<\/a>, and <a href=\"https:\/\/en.wiktionary.org\/wiki\/somatomotor\" target=\"_blank\" rel=\"noopener\">somatomotor<\/a> symptom cluster ratings were associated with alteration to CAN topology in patients, depending on the frequency band. These findings provide evidence for reduced higher-order homeostatic regulation and adaptability in ME\/CFS. If confirmed, these findings address the CAN as a potential therapeutic target for managing patient symptoms.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cortical autonomic network connectivity predicts symptoms in myalgic encephalomyelitis\/ chronic fatigue syndrome (ME\/CFS), by Mark A Zinn, Leonard A Jason in International Journal of Psychophysiology Vol 170, Dec 2021, Pages 89-101 [doi.org\/10.1016\/j.ijpsycho.2021.10.004] &nbsp; Highlights The findings of this study contribute &hellip; <a href=\"https:\/\/wames.org.uk\/cms-english\/research-can-connectivity-predicts-symptoms-in-me-cfs\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[930,6866,603,4152,2456,2241],"class_list":["post-33207","post","type-post","status-publish","format-standard","hentry","category-news","tag-autonomic-nervous-system","tag-central-autonomic-network","tag-depaul-symptom-questionnaire","tag-eloreta","tag-mark-a-zinn","tag-prof-leonard-jason"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-8DB","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/33207","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=33207"}],"version-history":[{"count":3,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/33207\/revisions"}],"predecessor-version":[{"id":33239,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/33207\/revisions\/33239"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=33207"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=33207"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=33207"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}