{"id":33241,"date":"2021-11-12T08:52:42","date_gmt":"2021-11-12T08:52:42","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=33241"},"modified":"2021-11-12T08:52:42","modified_gmt":"2021-11-12T08:52:42","slug":"research-review-pain-related-post-exertional-malaise-in-me-cfs-fm","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/research-review-pain-related-post-exertional-malaise-in-me-cfs-fm\/","title":{"rendered":"Research review: Pain-related post-exertional malaise in ME\/CFS & FM"},"content":{"rendered":"

Pain-related post-exertional malaise in Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS) and Fibromyalgia: a systematic review and three-level meta-analysis<\/a>, by Ellen E Barhorst, Alex E Boruch, Dane B Cook in<\/span> Pain Medicine<\/em>, October 2021 [DOI:10.1093\/pm\/pnab308]<\/h3>\n

 <\/p>\n

Review abstract:<\/strong><\/p>\n

Objective: <\/strong><\/p>\n

\"\"Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS) and Fibromyalgia (FM) are two debilitating, moderately comorbid illnesses in which chronic musculoskeletal pain<\/a> symptoms are prevalent. These individuals can experience post-exertional malaise<\/a> (PEM), a phenomenon where symptom severity is worsened 24hr or longer following physical stress, but the pain-related component of PEM is not well characterized.<\/p>\n

Design: <\/strong><\/p>\n

Systematic review and meta-analysis.<\/p>\n

Methods:<\/strong><\/p>\n

Case-control studies involving adults with ME\/CFS or FM and measuring pain symptoms before and after exposure to a standardized aerobic exercise test were included. Hedges’ d effect sizes<\/a> were aggregated using random effects models and potential moderators were explored with meta-regression analysis<\/a>. Results were adjusted for nesting effects using three-level modeling<\/a>.<\/p>\n

Results: <\/strong><\/p>\n

Forty-five effects were extracted from 15 studies involving 306 patients and 292 healthy controls. After adjusting for nesting effects, we observed a small-to-moderate effect indicating higher post-exercise pain in patients than controls (Hedges’ d=0.42; 95% CI: 0.16, 0.67). The mean effect was significantly moderated by pain measurement timepoint (b = -0.19, z = -2.57, P = 0.01) such that studies measuring pain 8-72hr post-exercise showed larger effects (d = 0.71, 95% CI = 0.28-1.14) than those measuring pain 0-2hr post-exercise (d = 0.32, 95% CI = 0.10-0.53).<\/p>\n

Conclusions: <\/strong><\/p>\n

People with ME\/CFS and FM experience small-to-moderate increases in pain severity following exercise which confirms pain as a component of PEM and emphasizes its debilitating impact in ME\/CFS and FM. Future directions include determining mechanisms of pain-related PEM and developing exercise prescriptions that minimize symptom exacerbation in these illnesses.<\/p>\n","protected":false},"excerpt":{"rendered":"

Pain-related post-exertional malaise in Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS) and Fibromyalgia: a systematic review and three-level meta-analysis, by Ellen E Barhorst, Alex E Boruch, Dane B Cook in Pain Medicine, October 2021 [DOI:10.1093\/pm\/pnab308]   Review abstract: Objective: Myalgic Encephalomyelitis\/Chronic Fatigue … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[7108,7109,250,1010,7107,251,252,503,584,585],"class_list":["post-33241","post","type-post","status-publish","format-standard","hentry","category-news","tag-alex-e-boruch","tag-chronic-musculoskeletal-pain","tag-chronic-pain","tag-dr-dane-b-cook","tag-ellen-e-barhorst","tag-fibromyalgia","tag-fm","tag-pain","tag-pem","tag-post-exertional-malaise"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-8E9","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/33241","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=33241"}],"version-history":[{"count":5,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/33241\/revisions"}],"predecessor-version":[{"id":33468,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/33241\/revisions\/33468"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=33241"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=33241"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=33241"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}