{"id":33387,"date":"2021-11-26T07:59:42","date_gmt":"2021-11-26T07:59:42","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=33387"},"modified":"2021-11-26T08:02:24","modified_gmt":"2021-11-26T08:02:24","slug":"research-limbic-perfusion-is-reduced-in-patients-with-me-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/research-limbic-perfusion-is-reduced-in-patients-with-me-cfs\/","title":{"rendered":"Research: Limbic perfusion is reduced in patients with ME\/CFS"},"content":{"rendered":"

Limbic perfusion is reduced in patients with Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS)<\/a>, by Xia Li, Per Julin and Tie-Qiang Li in<\/span> Tomography<\/em> 2021, 7(4), 675-687; [doi.org\/10.3390\/tomography7040056] 1 Nov 2021<\/h3>\n

 <\/p>\n

Research abstract:<\/strong><\/h3>\n

Myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) is an illness characterized by a diverse range of debilitating symptoms including autonomic, immunologic, and cognitive dysfunction. Although neurological and cognitive aberrations have been consistently reported, relatively little is known regarding the regional cerebral blood flow<\/a> (rCBF) in ME\/CFS.<\/p>\n

\"\"<\/p>\n

In this study, we studied a cohort of 31 ME\/CSF patients (average age: 42.8 \u00b1 13.5 years) and 48 healthy controls (average age: 42.9 \u00b1 12.0 years) using the pseudo-continuous arterial spin labeling (PCASL<\/a>) technique on a whole-body clinical 3T MRI scanner<\/a>.<\/p>\n

Besides routine clinical MRI, the protocol included a session of over 8 min-long rCBF measurement. The differences in the rCBF between the ME\/CSF patients and healthy controls were statistically assessed with voxel-wise and AAL ROI-based two-sample t-tests<\/a>. Linear regression analysis<\/a> was also performed on the rCBF data by using the symptom severity score as the main regressor.<\/p>\n

\n

Hypoperfusion<\/strong> is a term that describes “a reduced amount of blood flow”<\/h3>\n<\/blockquote>\n

In comparison with the healthy controls, the patient group showed significant hypoperfusion<\/a> (uncorrected voxel wise\u00a0p\u00a0\u2264 0.001, FWE\u00a0p\u00a0\u2264 0.01) in several brain regions of the limbic system<\/a>, including the anterior cingulate cortex, putamen, pallidum, and anterior ventral insular area. For the ME\/CFS patients, the overall symptom severity score at rest was significantly associated with a reduced rCBF in the anterior cingulate cortex<\/a>.<\/p>\n

\n

In the human brain, the anterior cingulate cortex<\/strong> (ACC) is involved in certain higher-level functions, such as attention allocation, reward anticipation, decision-making, ethics and morality, impulse control (e.g. performance monitoring and error detection), and emotion. [Wikipedia]<\/h3>\n<\/blockquote>\n

The results of this study show that brain blood flow abnormalities in the limbic system may contribute to ME\/CFS pathogenesis.<\/p>\n","protected":false},"excerpt":{"rendered":"

Limbic perfusion is reduced in patients with Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS), by Xia Li, Per Julin and Tie-Qiang Li in Tomography 2021, 7(4), 675-687; [doi.org\/10.3390\/tomography7040056] 1 Nov 2021   Research abstract: Myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) is an illness … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[7076,798,7122,1174,1027,1037,5276,7103,7121,5661,7123],"class_list":["post-33387","post","type-post","status-publish","format-standard","hentry","category-news","tag-anterior-cingulate-cortex","tag-cerebral-blood-flow","tag-hypoperfusion","tag-limbic-system","tag-magnetic-resonance-imaging","tag-mri","tag-per-julin","tag-pseudo-continuous-arterial-spin-labeling","tag-statistical-analysis","tag-tie-qiang-li","tag-xia-li"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-8Gv","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/33387","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=33387"}],"version-history":[{"count":4,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/33387\/revisions"}],"predecessor-version":[{"id":33615,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/33387\/revisions\/33615"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=33387"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=33387"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=33387"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}