{"id":33605,"date":"2021-11-24T08:51:56","date_gmt":"2021-11-24T08:51:56","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=33605"},"modified":"2021-11-24T08:52:22","modified_gmt":"2021-11-24T08:52:22","slug":"hypothesis-an-attempt-to-explain-the-neurological-symptoms-of-me-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/hypothesis-an-attempt-to-explain-the-neurological-symptoms-of-me-cfs\/","title":{"rendered":"Hypothesis: An attempt to explain the neurological symptoms of ME\/CFS"},"content":{"rendered":"

An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis\/ Chronic Fatigue Syndrome,<\/a> by Klaus J Wirth, Carmen Scheibenbogen & Friedemann Paul in<\/span>\u00a0Journal of Translational Medicine<\/em> volume 19, no: 471 (2021)<\/h3>\n

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Review abstract<\/strong><\/h3>\n

There is accumulating evidence of endothelial dysfunction, muscle and cerebral hypoperfusion in Myalgic Encephalomyelitis\/ Chronic Fatigue Syndrome (ME\/CFS).<\/p>\n

In this paper we deduce the pathomechanisms resulting in central nervous pathology and the myriad of neurocognitive symptoms. We outline tentative mechanisms of impaired cerebral blood flow<\/a>, increase in intracranial pressure<\/a> and central adrenergic hyperactivity<\/a> and how they can well explain the key symptoms of cognitive impairment<\/a>, brain fog<\/a>, headache<\/a>, hypersensitivity<\/a>, sleep disturbances<\/a> and dysautonomia<\/a>.<\/p>\n

Excerpt from Introduction<\/strong><\/h3>\n
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Key neurological pathomechanisms in ME\/CFS<\/p><\/div>\n

ME\/CFS is classified as a neurological disease. This is based on neurological symptoms including mental fatigue, impaired cognition, psychomotor slowing, disturbed sleep, hypersensitivities to noise, light and smells, headache, pain and paresthesias and severe dysautonomia.<\/p>\n

Many symptoms are, however, not obviously explained by neurological pathology including the cardiovascular situation with orthostatic intolerance, hypovolemia and a low activity of the renin\u2013angiotensin\u2013aldosterone system (RAAS), or the impaired muscle function (reduced handgrip strength and fatigability) and energetic disturbance. This co-occurrence of seemingly unrelated symptoms and findings prompts to look for a unifying explanation (the most parsimonious explanation).<\/p>\n

\u00a0The authors discuss:<\/strong><\/p>\n