{"id":34059,"date":"2022-02-04T08:42:05","date_gmt":"2022-02-04T08:42:05","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=34059"},"modified":"2022-02-04T08:42:05","modified_gmt":"2022-02-04T08:42:05","slug":"long-covid-research-use-of-cpet-to-understand-dyspnea-assess-for-me-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/long-covid-research-use-of-cpet-to-understand-dyspnea-assess-for-me-cfs\/","title":{"rendered":"Long COVID research: Use of CPET to understand dyspnea & assess for ME\/CFS"},"content":{"rendered":"

Use of cardiopulmonary stress testing for patients with unexplained dyspnea Ppost\u2013Coronavirus Disease<\/a>, by Donna M Mancini, Danielle L Brunjes, Anuradha Lala, Maria Giovanna Trivieri, Johanna P Contreras, and Benjamin H Natelson in<\/span> J Am Coll Cardiol HF<\/em> 2021 Dec, 9 (12) 927\u2013937<\/h3>\n

 <\/p>\n

Research abstract:<\/strong><\/h3>\n

Objectives<\/strong>
\nThe authors used cardiopulmonary exercise testing<\/a> (CPET) to define unexplained dyspnea<\/a> in patients with post-acute sequelae of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection (PASC). We assessed participants for criteria to diagnose myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS).<\/p>\n

Background<\/strong>
\nApproximately 20% of patients who recover from coronavirus disease (COVID) remain symptomatic. This syndrome is named PASC. Its etiology is unclear. Dyspnea is a frequent symptom.<\/p>\n

Methods<\/strong>
\nThe authors performed CPET and symptom assessment for ME\/CFS in 41 patients with PASC 8.9 \u00b1 3.3 months after COVID. All patients had normal pulmonary function tests, chest X-ray, and chest computed tomography scans. Peak oxygen consumption (peak VO2), slope of minute ventilation to CO2\u00a0production (VE\/VCO2\u00a0slope), and end tidal pressure of CO2\u00a0(PetCO2) were measured. Ventilatory patterns were reviewed with dysfunctional breathing defined as rapid erratic breathing.<\/p>\n

Results<\/strong>
\nEighteen men and 23 women (average age: 45 \u00b1 13 years) were studied. Left ventricular ejection fraction was 59% \u00b1 9%. Peak VO2\u00a0averaged 20.3 \u00b1 7 mL\/kg\/min (77% \u00b1 21% predicted VO2). VE\/VCO2\u00a0slope was 30 \u00b1 7. PetCO2\u00a0at rest was 33.5 \u00b1 4.5 mm Hg. Twenty-four patients (58.5%) had a peak VO2\u00a0<80% predicted. All patients with peak VO2\u00a0<80% had a circulatory limitation to exercise. Fifteen of 17 patients with normal peak VO2\u00a0had ventilatory abnormalities including peak respiratory rate >55 (n = 3) or dysfunctional breathing (n = 12). For the whole cohort, 88% of patients (n = 36) had ventilatory abnormalities with dysfunctional breathing (n = 26), increased VE\/VCO2\u00a0(n = 17), and\/or hypocapnia PetCO2\u00a0<35 (n = 25). Nineteen patients (46%) met criteria for ME\/CFS.<\/p>\n

\"\"<\/p>\n

Conclusions<\/strong>
\nCirculatory impairment<\/a>, abnormal ventilatory pattern, and ME\/CFS are common in patients with PASC. The dysfunctional breathing, resting hypocapnia<\/a>, and ME\/CFS may contribute to symptoms. CPET is a valuable tool to assess these patients.<\/p>\n

 <\/p>\n

Physicians weekly:<\/strong> Abnormal ventilatory patterns common after COVID-19<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Use of cardiopulmonary stress testing for patients with unexplained dyspnea Ppost\u2013Coronavirus Disease, by Donna M Mancini, Danielle L Brunjes, Anuradha Lala, Maria Giovanna Trivieri, Johanna P Contreras, and Benjamin H Natelson in J Am Coll Cardiol HF 2021 Dec, 9 … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[7202,516,2816,517,6990,7201,2847,6532,7205,7204,7203,6930],"class_list":["post-34059","post","type-post","status-publish","format-standard","hentry","category-news","tag-anuradha-lala","tag-cardiopulmonary-exercise-testing","tag-circulatory-impairment","tag-cpet","tag-danielle-l-brunjes","tag-donna-m-mancini","tag-dr-benjamin-natelson","tag-dysfunctional-breathing","tag-dyspnea","tag-johanna-p-contreras","tag-maria-giovanna-trivieri","tag-shortness-of-breath"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-8Rl","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/34059","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=34059"}],"version-history":[{"count":2,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/34059\/revisions"}],"predecessor-version":[{"id":34066,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/34059\/revisions\/34066"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=34059"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=34059"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=34059"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}