{"id":34190,"date":"2022-02-22T08:28:33","date_gmt":"2022-02-22T08:28:33","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=34190"},"modified":"2022-02-22T08:28:33","modified_gmt":"2022-02-22T08:28:33","slug":"research-physiological-assessment-of-orthostatic-intolerance-in-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/research-physiological-assessment-of-orthostatic-intolerance-in-cfs\/","title":{"rendered":"Research: Physiological assessment of orthostatic intolerance in CFS"},"content":{"rendered":"

Physiological assessment of orthostatic intolerance in chronic fatigue syndrome<\/a> by Benjamin H Natelson, Jin-Mann S Lin, Michelle Blate, Sarah Khan, Yang Chen\u00a0&
\nElizabeth R Unger in<\/span> Journal of Translational Medicine<\/em> vol 20, no: 95 (2022)<\/h3>\n

 <\/p>\n

Research abstract:<\/strong><\/h3>\n

Background<\/strong>
\n\"\"Orthostatic intolerance-OI is common in Myalgic Encephalomyelitis \/Chronic Fatigue Syndrome -ME\/CFS. We used a 10-min passive vertical lean test<\/a> as orthostatic challenge<\/a>-OC and measured changes in vitals and end tidal CO2\u00a0(eTCO2). An abnormal physiologic response to OC was identified in 60% of the 63 patients evaluated from one to three times over several years. Hypocapnia<\/a>, either resting or induced by OC, was the most frequent abnormality, followed by postural orthostatic tachycardia.<\/a><\/p>\n

Objective<\/strong>
\nEvaluate the physiologic response of patients with ME\/CFS to a standardized OC.<\/p>\n

Design<\/strong>
\nRespiratory and heart rate, blood pressure and eTCO2\u00a0were recorded twice at the end of 10-min supine rest and then every minute during the 10-min lean. Hypocapnia was eTCO2\u2009\u2264\u200932\u00a0mmHg. Orthostatic tachycardia was heart rate increase\u2009\u2265\u200930 beats per minute\u00a0compared with resting or\u2009\u2265\u2009120 BPM. Orthostatic hypotension<\/a> was decreased systolic pressure\u2009\u2265\u200920\u00a0mmHg from baseline. Tachypnea<\/a> was respiratory rate of\u00a0\u2009\u2265\u200920 breaths per minute\u2014either supine or leaning. Questionnaire data on symptom severity, quality of life and mood were collected at visit #2.<\/p>\n

Patients<\/strong>
\n63 consecutive patients fulfilling the 1994 case definition for CFS underwent lean testing at first visit and then annually at visit 2 (n\u2009=\u200948) and 3 (n\u2009=\u200929).<\/p>\n

Measures<\/strong>
\nSupine hypocapnia; orthostatic tachycardia, hypocapnia or hypotension.<\/p>\n

Results<\/strong>
\nThe majority of ME\/CFS patients (60.3%, 38\/63) had an abnormality detected during a lean test at any visit (51%, 50% and 45% at visits 1, 2 and 3, respectively). Hypocapnia<\/a> at rest or induced by OC was more common and more likely to persist than postural orthostatic tachycardia. Anxiety scores did not differ between those with and without hypocapnia.<\/p>\n

Conclusions<\/strong>
\nThe 10-min lean test is useful in evaluation of OI in patients with ME\/CFS. The most frequent abnormality, hypocapnia, would be missed without capnography<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Physiological assessment of orthostatic intolerance in chronic fatigue syndrome by Benjamin H Natelson, Jin-Mann S Lin, Michelle Blate, Sarah Khan, Yang Chen\u00a0& Elizabeth R Unger in Journal of Translational Medicine vol 20, no: 95 (2022)   Research abstract: Background Orthostatic … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[7221,2847,2540,7220,4242,7219,6764,493,492,332,331,5349,5664],"class_list":["post-34190","post","type-post","status-publish","format-standard","hentry","category-news","tag-capnography","tag-dr-benjamin-natelson","tag-dr-elizabeth-unger","tag-hypocapnia","tag-jin-mann-s-lin","tag-michelle-blate","tag-nasa-lean-test","tag-oi","tag-orthostatic-intolerance","tag-postural-orthostatic-tachycardia-syndrome","tag-pots","tag-sarah-khan","tag-yang-chen"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-8Ts","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/34190","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=34190"}],"version-history":[{"count":1,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/34190\/revisions"}],"predecessor-version":[{"id":34191,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/34190\/revisions\/34191"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=34190"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=34190"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=34190"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}