{"id":34509,"date":"2022-03-14T08:51:43","date_gmt":"2022-03-14T08:51:43","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=34509"},"modified":"2022-03-14T08:57:10","modified_gmt":"2022-03-14T08:57:10","slug":"research-predictors-for-developing-severe-me-cfs-following-infectious-mononucleosis","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/research-predictors-for-developing-severe-me-cfs-following-infectious-mononucleosis\/","title":{"rendered":"Research: Predictors for developing severe ME\/CFS following infectious Mononucleosis"},"content":{"rendered":"

Predictors for developing severe Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome following infectious Mononucleosis<\/a>, by Leonard A Jason, Joseph Cotler, Mohammed F Islam, Jacob Furst, Ben Z Katz in<\/span> Journal of Rehabilitation Therapy<\/em>, 2022;4(1):1-5, February 21, 2022<\/h3>\n

 <\/p>\n

Research abstract:<\/strong><\/h3>\n

Background<\/strong>:<\/p>\n

About 10% of individuals who contract infectious mononucleosis<\/a> (IM) [aka Glandular fever] have symptoms 6 months later that meet criteria for myalgic encephalomyelitis\/ chronic fatigue syndrome (ME\/CFS).\u00a0 Our study for the first time examined whether it is possible to predict who will develop ME\/CFS following IM.<\/p>\n

Methods: <\/strong><\/p>\n

We have reported on a prospectively recruited cohort of 4,501 college students, of which 238 (5.3%) developed IM.\u00a0 Those who developed IM were followed-up at six months to determine whether they recovered or met criteria for ME\/CFS. The present study focuses on 48 students who after six months had a diagnosis of ME\/CFS, and a matched control group of 58 students who had no further symptoms after their IM.<\/p>\n

All of these 106 students \u00a0had data at baseline (at least 6 weeks prior to the development of IM), when experiencing IM, and 6 months following IM. Of those who did not recover from IM, there were two groups: 30 were classified as ME\/CFS and 18 were classified as severe ME\/CFS.<\/p>\n

We measured the results of 7 questionnaires, physical examination findings, the severity of mononucleosis and cytokine analyses at baseline (pre-illness) and at the time of IM.\u00a0 We examined predictors (e.g., pre-illness variables as well as variables at onset of IM) of \u00a0those who developed ME\/CFS and severe ME\/CFS following IM.<\/p>\n

Results: <\/strong><\/p>\n

\"\"From analyses using receiver operating characteristic statistics<\/a>, the students who had had severe gastrointestinal symptoms of stomach pain, bloating, and an irritable bowel at baseline\u00a0 and who also had abnormally low levels of the immune markers IL-13 and\/or IL-5 at baseline, as well as severe gastrointestinal symptoms when then contracted IM,\u00a0 were found to have a nearly 80% chance of having severe ME\/CFS persisting six months following IM.<\/p>\n

Conclusions: <\/strong><\/p>\n

Our findings are consistent with emerging literature that gastrointestinal distress and autonomic symptoms, along with several immune markers, may be implicated in the development of severe ME\/CFS.<\/p>\n

Extract from Discussion:<\/strong><\/p>\n

The current study for the first time attempted to predict onset of ME\/CFS using pre-illness and illness data. If validated, these predictors of risk could significantly alter the therapeutic strategies in IM and other triggers of ME\/CFS in adults and adolescents. In addition, our work may lead to a reappraisal of the ME\/CFS diagnostic criteria to include objective gastrointestinal and\/or autonomic criteria for diagnosis.<\/p>\n","protected":false},"excerpt":{"rendered":"

Predictors for developing severe Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome following infectious Mononucleosis, by Leonard A Jason, Joseph Cotler, Mohammed F Islam, Jacob Furst, Ben Z Katz in Journal of Rehabilitation Therapy, 2022;4(1):1-5, February 21, 2022   Research abstract: Background: About 10% … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[4180,113,636,3814,4614,6008,2241,36],"class_list":["post-34509","post","type-post","status-publish","format-standard","hentry","category-news","tag-ben-z-katz","tag-cytokines","tag-infectious-mononucleosis","tag-jacob-furst","tag-joseph-cotler","tag-mohammed-f-islam","tag-prof-leonard-jason","tag-severe-me"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-8YB","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/34509","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=34509"}],"version-history":[{"count":4,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/34509\/revisions"}],"predecessor-version":[{"id":34567,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/34509\/revisions\/34567"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=34509"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=34509"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=34509"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}