{"id":35888,"date":"2022-08-01T22:47:33","date_gmt":"2022-08-01T21:47:33","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=35888"},"modified":"2022-08-01T22:47:33","modified_gmt":"2022-08-01T21:47:33","slug":"research-epstein-barr-virus-in-me-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/research-epstein-barr-virus-in-me-cfs\/","title":{"rendered":"Research: Epstein-Barr Virus in ME\/CFS"},"content":{"rendered":"<h2><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9263839\/\" target=\"_blank\" rel=\"noopener\"><strong>Revisiting IgG antibody reactivity to Epstein-Barr Virus in Myalgic Encephalomyelitis\/ Chronic Fatigue Syndrome and its potential application to disease diagnosis<\/strong><\/a><\/h2>\n<h3><\/h3>\n<h3><strong>Key research findings:<\/strong><\/h3>\n<ul>\n<li>Epstein-Barr virus (EBV) infection is commonly reported at the onset of ME\/CFS, but could <a href=\"https:\/\/my.clevelandclinic.org\/health\/body\/22971-antibodies\" target=\"_blank\" rel=\"noopener\">antibodies<\/a> against EBV serve as <a href=\"https:\/\/en.wikipedia.org\/wiki\/Biomarker\" target=\"_blank\" rel=\"noopener\">biomarkers<\/a> of the disease?<\/li>\n<li>No differences in antibody responses were found between blood samples from 92 ME\/CFS patients and 50 healthy control subjects.<\/li>\n<li>However, when analysing only patients with a reported infectious onset of disease, antibody responses against two EBV-related antigens were stronger in the patient group; these results need confirmation.<\/li>\n<\/ul>\n<h3><strong>Research abstract:<\/strong><\/h3>\n<p><img data-recalc-dims=\"1\" decoding=\"async\" class=\"alignright size-medium wp-image-36093 lazyload\" data-src=\"https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2022\/08\/Epstein-Barr-illnesses.jpg?resize=300%2C220&#038;ssl=1\" alt=\"\" width=\"300\" height=\"220\" data-srcset=\"https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2022\/08\/Epstein-Barr-illnesses.jpg?resize=300%2C220&amp;ssl=1 300w, https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2022\/08\/Epstein-Barr-illnesses.jpg?resize=150%2C110&amp;ssl=1 150w, https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2022\/08\/Epstein-Barr-illnesses.jpg?w=717&amp;ssl=1 717w\" data-sizes=\"(max-width: 300px) 100vw, 300px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 300px; --smush-placeholder-aspect-ratio: 300\/220;\" \/>Infections by the Epstein-Barr virus (EBV) are often at the disease onset of patients suffering from Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS). However, <a href=\"https:\/\/www.britannica.com\/science\/serological-test\" target=\"_blank\" rel=\"noopener\">serological analyses<\/a> of these infections remain inconclusive when comparing patients with healthy controls (HCs). In particular, it is unclear if certain EBV-derived antigens eliciting antibody responses have a biomarker potential for disease diagnosis.<\/p>\n<p>With this purpose, we re-analyzed a previously published microarray data on the IgG antibody responses against 3,054 EBV-related antigens in 92 patients with ME\/CFS and 50 HCs. This re-analysis consisted of constructing different regression models for binary outcomes with the ability to classify patients and HCs. In these models, we tested for a possible interaction of different antibodies with age and gender. When analyzing the whole data set, there were no antibody responses that could distinguish patients from healthy controls.<\/p>\n<p>A similar finding was obtained when comparing patients with non-infectious or unknown disease trigger with healthy controls. However, when data analysis was restricted to the comparison between HCs and patients with a putative infection at their disease onset, we could identify stronger antibody responses against two candidate antigens (EBNA4_0529 and EBNA6_0070).<\/p>\n<p>Using antibody responses to these two antigens together with age and gender, the final classification model had an estimated sensitivity and specificity of 0.833 and 0.720, respectively. This reliable case-control discrimination suggested the use of the antibody levels related to these candidate viral epitopes as biomarkers for disease diagnosis in this subgroup of patients.<\/p>\n<p>To confirm this finding, a follow-up study will be conducted in a separate cohort of patients.<\/p>\n<p>&nbsp;<\/p>\n<h3><strong>Research authors &amp; location:<\/strong><\/h3>\n<p>Nuno Sep\u00falveda, Jo\u00e3o Malato, Franziska Sotzny, Anna D Grabowska, Andr\u00e9 Fonseca, Clara Cordeiro, Lu\u00eds Gra\u00e7a, Przemyslaw Biecek, Uta Behrends, Josef Mautner, Francisco Westermeier, Eliana M Lacerda, Carmen Scheibenbogen <span style=\"text-decoration: underline;\">in<\/span>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9263839\/\" target=\"_blank\" rel=\"noopener\"><em>Front Med<\/em><\/a> (Lausanne). 2022 Jun 24;9:921101 [doi: 10.3389\/fmed.2022.921101] eCollection 2022.<\/p>\n<p>ME Research UK:\u00a0<a href=\"https:\/\/www.meresearch.org.uk\/research\/antibody-reactivity-to-ebv\/\">Revisiting IgG antibody reactivity to EBV in ME\/CFS and its potential application to disease diagnosis (meresearch.org.uk)<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Revisiting IgG antibody reactivity to Epstein-Barr Virus in Myalgic Encephalomyelitis\/ Chronic Fatigue Syndrome and its potential application to disease diagnosis Key research findings: Epstein-Barr virus (EBV) infection is commonly reported at the onset of ME\/CFS, but could antibodies against EBV &hellip; <a href=\"https:\/\/wames.org.uk\/cms-english\/research-epstein-barr-virus-in-me-cfs\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[7001,5920,4267,7003,7213,3529,224,4577,7000,7301,7002,4986,7302,6878],"class_list":["post-35888","post","type-post","status-publish","format-standard","hentry","category-news","tag-andre-fonseca","tag-anna-d-grabowska","tag-carmen-scheibenbogen","tag-clara-cordeiro","tag-dr-francisco-westermeier","tag-eliana-m-lacerda","tag-epstein-barr-virus","tag-franziska-sotzny","tag-joao-malato","tag-josef-mautner","tag-luis-graca","tag-nuno-sepulveda","tag-przemyslaw-biecek","tag-uta-behrends"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-9kQ","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/35888","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=35888"}],"version-history":[{"count":3,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/35888\/revisions"}],"predecessor-version":[{"id":36094,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/35888\/revisions\/36094"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=35888"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=35888"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=35888"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}