{"id":35935,"date":"2022-07-27T08:40:09","date_gmt":"2022-07-27T07:40:09","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=35935"},"modified":"2022-07-27T08:41:03","modified_gmt":"2022-07-27T07:41:03","slug":"research-metabolomic-evidence-for-peroxisomal-dysfunction-in-me-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/research-metabolomic-evidence-for-peroxisomal-dysfunction-in-me-cfs\/","title":{"rendered":"Research: Metabolomic evidence for peroxisomal dysfunction in ME\/CFS"},"content":{"rendered":"

Metabolomic evidence for peroxisomal dysfunction in Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome<\/strong><\/a><\/h2>\n

 <\/p>\n

Research conclusion:<\/strong><\/h3>\n

Our findings provide the first metabolomic<\/a> evidence of peroxisomal dysfunction<\/a>, and are consistent with dysregulation of lipid<\/a> remodeling and the tricarboxylic acid cycle.<\/a> These findings, if validated in other cohorts, could provide new insights into the pathogenesis of ME\/CFS and highlight the potential use of the plasma metabolome<\/a> as a source of biomarkers for the disease.<\/p>\n

Peroxisomes are small structures (organelles) inside a cell that perform specific functions to keep that cell alive. Mitochondria is an organelle which makes energy. Peroxisome regulates biochemical pathways that involve oxidation. (Study.com<\/a>)<\/p><\/blockquote>\n

Research abstract:<\/strong><\/h3>\n

Myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) is a chronic and debilitating disease characterized by unexplained physical fatigue, cognitive and sensory dysfunction, sleeping disturbances, orthostatic intolerance, and gastrointestinal problems.<\/p>\n

\"\"

Persoxisome<\/p><\/div>\n

People with ME\/CFS often report a prodrome<\/a> consistent with infections. Using regression, Bayesian and enrichment analyses, we conducted targeted and untargeted metabolomic analysis of plasma<\/a> from 106 ME\/CFS cases and 91 frequency-matched healthy controls.<\/p>\n

Subjects in the ME\/CFS group had significantly decreased levels of plasmalogens and phospholipid ethers (p<0.001), phosphatidylcholines (p<0.001) and sphingomyelins (p<0.001), and elevated levels of dicarboxylic acids (p=0.013). Using machine learning algorithms, we were able to differentiate ME\/CFS or subgroups of ME\/CFS from controls with area under the receiver operating characteristic curve (AUC) values up to 0.873.<\/p>\n

Metabolomics is the screening for characteristic substances in body fluids and tissue, which serve as direct marker of biochemical activity<\/p><\/blockquote>\n

Comment: <\/strong><\/h3>\n

Peroxisomes, Mitochondria, & Fibrinoid Microclots<\/a>, by John Duncan<\/p>\n

Authors:<\/strong><\/h3>\n

Xiaoyu Che, Christopher R Brydges, Yuanzhi Yu, Adam Price, Shreyas Joshi, Ayan Roy, Bohyun Lee, Dinesh K Barupal, Aaron Cheng, Dana March Palmer, Susan Levine, Daniel L Peterson, Suzanne D Vernon, Lucinda Bateman, Mady Hornig, Jose G Montoya, Anthony L Komaroff, Oliver Fiehn, W Ian Lipkin<\/p>\n

Article location:\u00a0<\/strong><\/h3>\n

International Journal of Molecular Sciences<\/a> Vol 23, #14, p 7906, July 18, 2022<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Metabolomic evidence for peroxisomal dysfunction in Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome   Research conclusion: Our findings provide the first metabolomic evidence of peroxisomal dysfunction, and are consistent with dysregulation of lipid remodeling and the tricarboxylic acid cycle. These findings, if validated … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[6083,7288,7294,4170,4527,7292,7289,7293,4528,1153,1128,59,2530,35,1262,7290,801,4012,4522,7295,3170,7291],"class_list":["post-35935","post","type-post","status-publish","format-standard","hentry","category-news","tag-aaron-cheng","tag-adam-price","tag-ayan-roy","tag-biomarker","tag-bohyun-lee","tag-christopher-r-brydges","tag-cytidine-5-diphosphocholine-pathway","tag-dana-march-palmer","tag-dinesh-k-barupal","tag-dr-daniel-peterson","tag-dr-ian-lipkin","tag-dr-lucinda-bateman","tag-dr-susan-levine","tag-dr-suzanne-vernon","tag-metabolomics","tag-peroxisome","tag-prof-anthony-komaroff","tag-prof-jose-montoya","tag-prof-oliver-fiehn","tag-shreyas-joshi","tag-tricarboxylic-acid-cycle","tag-yuanzhi-yu"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-9lB","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/35935","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=35935"}],"version-history":[{"count":4,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/35935\/revisions"}],"predecessor-version":[{"id":36020,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/35935\/revisions\/36020"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=35935"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=35935"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=35935"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}