{"id":37050,"date":"2022-10-13T22:56:41","date_gmt":"2022-10-13T21:56:41","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=37050"},"modified":"2022-10-13T23:02:15","modified_gmt":"2022-10-13T22:02:15","slug":"research-orthostatic-intolerance-neurocognitive-impairment-overlap-in-me-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/research-orthostatic-intolerance-neurocognitive-impairment-overlap-in-me-cfs\/","title":{"rendered":"Research: Orthostatic Intolerance & neurocognitive impairment overlap in ME\/CFS"},"content":{"rendered":"

Orthostatic Intolerance & neurocognitive impairment overlap in ME\/CFS<\/strong><\/h2>\n

 <\/p>\n

Prof Jason Leonard and US colleagues investigated the relationship between Orthostatic Intolerance and neurocognitive impairment in ME\/CFS<\/h3>\n

Orthostatic intolerance (OI) is the development of symptoms when standing upright that are relieved when reclining (Wikipedia<\/a>)<\/p><\/blockquote>\n

Conclusions<\/strong><\/h3>\n

Neurocognitive symptoms and OI overlap in ME\/CFS, and our results do not support the IOM<\/a>\u2019s inclusion of neurocognitive impairment<\/a> and OI<\/a> as interchangeable symptoms. Furthermore, our findings highlight the need for a uniform method of defining and measuring OI via self-report in order to accurately study OI as a symptom of ME\/CFS.<\/p>\n

\"\"

Neurocognitive domains. The DSM-5 defines 6 key domains of cognitive function – Sachdev et al<\/p><\/div>\n

 <\/p>\n

Orthostatic intolerance and neurocognitive impairment in Myalgic Encephalomyelitis\/ Chronic Fatigue Syndrome (ME\/CFS)<\/a>, by Caroline L Gaglio, Mohammed F Islam, Joseph Cotler and Leonard A Jason in<\/span> Epidemiologic Methods <\/em>October 10, 2022 [doi.org\/10.1515\/em-2021-0033]<\/h3>\n

Research abstract<\/strong><\/h3>\n

Objectives<\/strong>
\nThe Institute of Medicine (IOM 2015. Beyond Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome: Redefining an Illness.<\/a> Washington: The National Academies Press) suggested new criteria for Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS), which requires an endorsement of either neurocognitive impairment or orthostatic intolerance (OI) in addition to other core symptoms.<\/p>\n

While some research supports the inclusion of OI as a core symptom, others argue that overlap with neurocognitive impairment does not justify the either\/or option. The current study assessed methods of operationalizing OI using items from the DePaul Symptom Questionnaire<\/a> (DSQ-1 and -2) as a part of the IOM criteria. Evaluating the relationship between OI and neurocognitive symptoms may lead to a better understanding of diagnostic criteria for ME\/CFS.<\/p>\n

Methods<\/strong>
\nTwo-hundred and forty-two participants completed the DSQ. We examined how many participants met the IOM criteria while endorsing different frequencies and severities of various OI symptoms.<\/p>\n

Results<\/strong>
\nNeurocognitive impairment was reported by 93.4% of respondents. OI without concurrent neurocognitive symptoms only allowed for an additional 1.7\u20134.5% of participants to meet IOM criteria.<\/p>\n

Conclusions<\/strong>
\nNeurocognitive symptoms and OI overlap in ME\/CFS, and our results do not support the IOM\u2019s inclusion of neurocognitive impairment and OI as interchangeable symptoms.<\/p>\n

Furthermore, our findings highlight the need for a uniform method of defining and measuring OI via self-report in order to accurately study OI as a symptom of ME\/CFS.<\/p>\n

The full paper is behind a paywall<\/em><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Orthostatic Intolerance & neurocognitive impairment overlap in ME\/CFS   Prof Jason Leonard and US colleagues investigated the relationship between Orthostatic Intolerance and neurocognitive impairment in ME\/CFS Orthostatic intolerance (OI) is the development of symptoms when standing upright that are relieved … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[7374,2792,1898,107,756,4614,6008,4151,493,492,2241],"class_list":["post-37050","post","type-post","status-publish","format-standard","hentry","category-news","tag-caroline-l-gaglio","tag-clinical-guidelines","tag-de-paul-symptom-questionnaire","tag-diagnostic-criteria","tag-iom","tag-joseph-cotler","tag-mohammed-f-islam","tag-neurocognitive-impairment","tag-oi","tag-orthostatic-intolerance","tag-prof-leonard-jason"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-9DA","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/37050","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=37050"}],"version-history":[{"count":6,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/37050\/revisions"}],"predecessor-version":[{"id":37058,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/37050\/revisions\/37058"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=37050"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=37050"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=37050"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}