{"id":38263,"date":"2023-02-15T17:05:04","date_gmt":"2023-02-15T17:05:04","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=38263"},"modified":"2023-04-30T17:41:33","modified_gmt":"2023-04-30T16:41:33","slug":"biomarker-research-differentiating-me-and-fm","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/biomarker-research-differentiating-me-and-fm\/","title":{"rendered":"Biomarker research: Differentiating ME and FM"},"content":{"rendered":"

Differentiating ME and FM <\/strong><\/h2>\n

 <\/p>\n

\"\"Canadian researchers believe they have uncovered a way to tell the difference between people with ME, FM and both ME + FM. 11 miRNAs (microRNAs) are proposed as potential biomarkers.<\/p>\n

microRNA is the name of a family of molecules that helps cells control the kinds and amounts of proteins they make. That is, cells use microRNA to help control gene expression.<\/p>\n

Molecules of microRNA are found in cells and in the bloodstream.<\/p>\n

Gene expression refers to whether a particular gene is making too much, too little or the normal amount of its protein at a particular time. OSU<\/a><\/p><\/blockquote>\n

Circulating microRNA expression signatures accurately discriminate myalgic encephalomyelitis from fibromyalgia and comorbid conditions<\/a>, by\u00a0Evguenia Nepotchatykh, Iurie Caraus, Wesam Elremaly, Corinne Leveau, Mohamed Elbakry, Christian Godbout, Bita Rostami-Afshari, Diana Petre, Nasrin Khatami, Anita Franco & Alain Moreau in<\/span>\u00a0Scientific Reports<\/em> volume 13, Article number: 1896 (2023)<\/p>\n

Research abstract:<\/strong><\/h3>\n

Myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS), and fibromyalgia<\/a>\u00a0(FM) are two chronic complex diseases with overlapping symptoms affecting multiple systems and organs over time. Due to the absence of validated biomarkers<\/a> and similarity in symptoms, both disorders are misdiagnosed, and the comorbidity of the two is often unrecognized.<\/p>\n

Our study aimed to investigate the expression profiles of 11 circulating miRNAs<\/a> previously associated with ME\/CFS pathogenesis in FM patients and individuals with a comorbid diagnosis of FM associated with ME\/CFS (ME\/CFS\u2009+\u2009FM), and matched sedentary healthy controls. Whether these 11 circulating miRNAs expression can differentiate between the two disorders was also examined.<\/p>\n

Our results highlight differential circulating miRNAs expression signatures between ME\/CFS, FM and ME\/CFS\u2009+\u2009FM, which also correlate to symptom severity between ME\/CFS and ME\/CFS\u2009+\u2009FM groups. We provided a prediction model, by using a machine-learning approach based on 11 circulating miRNAs levels, which can be used to discriminate between patients suffering from ME\/CFS, FM and ME\/CFS\u2009+\u2009FM. These 11 miRNAs are proposed as potential biomarkers for discriminating ME\/CFS from FM.<\/p>\n

The results of this study demonstrate that ME\/CFS and FM are two distinct illnesses, and we highlight the comorbidity between the two conditions. Proper diagnosis of patients suffering from ME\/CFS, FM or ME\/CFS\u2009+\u2009FM is crucial to elucidate the pathophysiology of both diseases, determine preventive measures, and establish more effective treatments.<\/p>\n","protected":false},"excerpt":{"rendered":"

Differentiating ME and FM   Canadian researchers believe they have uncovered a way to tell the difference between people with ME, FM and both ME + FM. 11 miRNAs (microRNAs) are proposed as potential biomarkers. microRNA is the name of … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[6358,7469,6366,6365,7468,6353,6369,251,6367,3381,6400,1182,7470,7467,6368],"class_list":["post-38263","post","type-post","status-publish","format-standard","hentry","category-news","tag-anita-franco","tag-bita-rostami-afshari","tag-christian-godbout","tag-corinne-leveau","tag-diana-petre","tag-dr-alain-moreau","tag-evguenia-nepotchatykh","tag-fibromyalgia","tag-iurie-carausus","tag-machine-learning","tag-micro-rna","tag-mirna","tag-mohamed-elbakry","tag-nasrin-khatami","tag-wesam-elremaly"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-9X9","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/38263","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=38263"}],"version-history":[{"count":3,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/38263\/revisions"}],"predecessor-version":[{"id":39052,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/38263\/revisions\/39052"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=38263"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=38263"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=38263"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}