{"id":38459,"date":"2023-03-09T09:05:53","date_gmt":"2023-03-09T09:05:53","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=38459"},"modified":"2023-03-09T09:08:00","modified_gmt":"2023-03-09T09:08:00","slug":"research-urine-another-way-to-show-inability-to-cope-with-exercise-in-me-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/research-urine-another-way-to-show-inability-to-cope-with-exercise-in-me-cfs\/","title":{"rendered":"Research: Urine – another way to show inability to cope with exercise in ME\/CFS"},"content":{"rendered":"

Urine shows abnormal reaction to exercise in ME\/CFS<\/strong><\/h2>\n

 <\/p>\n

A small study of 8 women gave surprising results when their urine was examined after an exercise test and compared to healthy people.<\/p>\n

“Our most unanticipated discovery is the lack of changes in the urine metabolome of ME\/CFS patients during recovery while significant changes are induced in controls after CPET, potentially demonstrating the lack of adaptation to a severe stress in ME\/CFS patients.”<\/p>\n

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“…significant differences were discovered between controls and ME\/CFS patients in many lipid (steroids, acyl carnitines and acyl glycines) and amino acid subpathways (cysteine, methionine, SAM, and taurine; leucine, isoleucine, and valine; polyamine; tryptophan; and urea cycle, arginine and proline).”<\/p>\n

\"\"<\/p>\n

To test the validity of these results researchers say that future studies should ensure BMI of participants is matched, diet is controlled and men are included.<\/p>\n

 <\/p>\n

Urine metabolomics exposes anomalous recovery after maximal exertion in female ME\/CFS patients<\/a> by Katherine A Glass, Arnaud Germain, Yuhsin V Huang and Maureen R Hanson in<\/span>\u00a0Int. J. Mol. Sci.<\/em> 2023, 24(4), 3685;[doi.org\/10.3390\/ijms24043685]<\/h3>\n

Research abstract:<\/strong><\/p>\n

Myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) is a debilitating disease with unknown etiology or effective treatments.<\/p>\n

Post-exertional malaise<\/a> (PEM) is a key symptom that distinguishes ME\/CFS patients. Investigating changes in the urine metabolome between ME\/CFS patients and healthy subjects following exertion may help us understand PEM.<\/p>\n

The aim of this pilot study was to comprehensively characterize the urine metabolomes<\/a> of eight female healthy sedentary control subjects and ten female ME\/CFS patients in response to a maximal cardiopulmonary exercise test<\/a> (CPET).<\/p>\n

Each subject provided urine samples at baseline and 24 h post-exercise. A total of 1403 metabolites<\/a> were detected via LC-MS\/MS by Metabolon\u00ae<\/a> including amino acids, carbohydrates, lipids, nucleotides, cofactors and vitamins, xenobiotics, and unknown compounds.<\/p>\n

Using a linear mixed effects model, pathway enrichment analysis, topology analysis, and correlations between urine and plasma metabolite levels, significant differences were discovered between controls and ME\/CFS patients in many lipid (steroids, acyl carnitines and acyl glycines) and amino acid subpathways (cysteine, methionine, SAM, and taurine; leucine, isoleucine, and valine; polyamine; tryptophan; and urea cycle, arginine and proline).<\/p>\n

Our most unanticipated discovery is the lack of changes in the urine metabolome of ME\/CFS patients during recovery while significant changes are induced in controls after CPET, potentially demonstrating the lack of adaptation to a severe stress in ME\/CFS patients.<\/p>\n","protected":false},"excerpt":{"rendered":"

Urine shows abnormal reaction to exercise in ME\/CFS   A small study of 8 women gave surprising results when their urine was examined after an exercise test and compared to healthy people. “Our most unanticipated discovery is the lack of … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[3398,517,1623,7471,1262,2823,4878,7472],"class_list":["post-38459","post","type-post","status-publish","format-standard","hentry","category-news","tag-arnaud-germain","tag-cpet","tag-exercise-tests","tag-katherine-a-glass","tag-metabolomics","tag-prof-maureen-hanson","tag-urine","tag-yuhsin-v-huang"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-a0j","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/38459","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=38459"}],"version-history":[{"count":6,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/38459\/revisions"}],"predecessor-version":[{"id":38642,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/38459\/revisions\/38642"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=38459"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=38459"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=38459"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}