{"id":38711,"date":"2023-04-06T08:38:39","date_gmt":"2023-04-06T07:38:39","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=38711"},"modified":"2023-04-06T08:38:39","modified_gmt":"2023-04-06T07:38:39","slug":"research-review-sleep-disruption-in-me-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/research-review-sleep-disruption-in-me-cfs\/","title":{"rendered":"Research review: Sleep disruption in ME\/CFS"},"content":{"rendered":"<h2><strong>Measurable sleep disruption in ME\/CFS\u00a0<\/strong><\/h2>\n<p><img data-recalc-dims=\"1\" decoding=\"async\" class=\"alignright wp-image-38856 lazyload\" data-src=\"https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2023\/04\/bloodshot-1294920_1280-e1680766261518-300x282.png?resize=250%2C235&#038;ssl=1\" alt=\"\" width=\"250\" height=\"235\" data-srcset=\"https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2023\/04\/bloodshot-1294920_1280-e1680766261518.png?resize=300%2C282&amp;ssl=1 300w, https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2023\/04\/bloodshot-1294920_1280-e1680766261518.png?resize=150%2C141&amp;ssl=1 150w, https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2023\/04\/bloodshot-1294920_1280-e1680766261518.png?resize=768%2C722&amp;ssl=1 768w, https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2023\/04\/bloodshot-1294920_1280-e1680766261518.png?w=800&amp;ssl=1 800w\" data-sizes=\"(max-width: 250px) 100vw, 250px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 250px; --smush-placeholder-aspect-ratio: 250\/235;\" \/><\/p>\n<p>Australian researchers reviewed the research which used objective measures, rather than patient surveys, to uncover the type and extent of sleep disruption in ME\/CFS.<\/p>\n<p><strong>Adult ME\/CFS patients:<\/strong><\/p>\n<ul>\n<li>spend longer time in bed<\/li>\n<li>longer sleep onset latency (the time it takes to fall asleep after turning the lights out)<\/li>\n<li>longer awake time after sleep onset<\/li>\n<li>reduced sleep efficiency (% of time asleep while in bed)<\/li>\n<li>decreased stage 2 sleep<\/li>\n<li>more Stage 3, and longer rapid eye movement sleep latency<\/li>\n<\/ul>\n<p><strong>Adolescent ME\/CFS patients had:<\/strong><\/p>\n<ul>\n<li>longer time in bed<\/li>\n<li>longer total sleep time<\/li>\n<li>longer sleep onset latency (the time it takes to fall asleep)<\/li>\n<li>reduced sleep efficiency (% of time spent asleep while in bed)<\/li>\n<\/ul>\n<h3><strong>The four broad stages of Non Rapid Eye Movement sleep include:<\/strong><\/h3>\n<ul>\n<li><strong>stage 1<\/strong> \u2013 dozing or drowsiness \u2013 you hover between being asleep and awake<\/li>\n<li><strong>stage 2<\/strong> \u2013you lose awareness of your surroundings, your body temperature starts to drop and your breathing and heart rate slow down<\/li>\n<li><strong>stages 3 and 4<\/strong> \u2013 deep sleep, also known as \u2018delta sleep\u2019 \u2013 your blood pressure, heart rate and breathing become very slow and your muscles relax. Growth and repair processes occur during this stage. [from: <a href=\"https:\/\/www.betterhealth.vic.gov.au\/health\/conditionsandtreatments\/sleep\" target=\"_blank\" rel=\"noopener\">Sleep explained<\/a>]<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1087079223000278\" target=\"_blank\" rel=\"noopener\">Objective sleep measures in chronic fatigue syndrome patients: a systematic review and meta-analysis,<\/a> by\u00a0Abdalla Z Mohamed, Thu Andersen, Sanja Radovic, Peter Del Fante, Richard Kwiatek, Vince Calhoun, Sandeep Bhuta, Daniel F Hermens, Jim Lagopoulos, Zack Y Shan <span style=\"text-decoration: underline;\">in<\/span> <em>Sleep Medicine Reviews <\/em>Vol 69, June 2023 [doi.org\/10.1016\/j.smrv.2023.101771]<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Research abstract<\/strong><\/p>\n<p>Patients with myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) often report disrupted and unrefreshing sleep in association with worsened fatigue symptoms.<\/p>\n<p>However, the nature and magnitude of sleep architecture alteration in ME\/CFS is not known, with studies using objective sleep measures in ME\/CFS generating contradictory results. The current manuscript aimed to review and meta-analyse of case-control studies with objective sleep measures in ME\/CFS. A search was conducted in PubMed, Scopus, Medline, Google Scholar, and Psychoinfo databases.<\/p>\n<p>After review, 24 studies were included in the meta-analysis, including 20 studies with 801 adults (ME\/CFS\u00a0=\u00a0426; controls\u00a0=\u00a0375), and 4 studies with 477 adolescents (ME\/CFS\u00a0=\u00a0242; controls\u00a0=\u00a0235), who underwent objective measurement of sleep.<\/p>\n<p>Adult ME\/CFS patients spend longer time in bed, longer sleep onset latency, longer awake time after sleep onset, reduced sleep efficiency, decreased stage 2 sleep, more Stage 3, and longer rapid eye movement sleep latency.<\/p>\n<p>However, adolescent ME\/CFS patients had longer time in bed, longer total sleep time, longer sleep onset latency, and reduced sleep efficiency.<\/p>\n<p>The meta-analysis results demonstrate that sleep is altered in ME\/CFS, with changes seeming to differ between adolescent and adults, and suggesting sympathetic and parasympathetic nervous system alterations in ME\/CFS.<\/p>\n<p><em>This research paper is behind a paywall but &#8220;Patients and caregivers can make requests for individual papers&#8230; at no cost.&#8221;<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Measurable sleep disruption in ME\/CFS\u00a0 Australian researchers reviewed the research which used objective measures, rather than patient surveys, to uncover the type and extent of sleep disruption in ME\/CFS. Adult ME\/CFS patients: spend longer time in bed longer sleep onset &hellip; <a href=\"https:\/\/wames.org.uk\/cms-english\/research-review-sleep-disruption-in-me-cfs\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[],"class_list":["post-38711","post","type-post","status-publish","format-standard","hentry","category-news"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-a4n","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/38711","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=38711"}],"version-history":[{"count":8,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/38711\/revisions"}],"predecessor-version":[{"id":38861,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/38711\/revisions\/38861"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=38711"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=38711"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=38711"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}