{"id":40666,"date":"2023-09-06T08:29:17","date_gmt":"2023-09-06T07:29:17","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=40666"},"modified":"2023-09-11T10:26:22","modified_gmt":"2023-09-11T09:26:22","slug":"biomarker-research-developing-a-blood-cell-based-diagnostic-test-with-raman-microscope","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/biomarker-research-developing-a-blood-cell-based-diagnostic-test-with-raman-microscope\/","title":{"rendered":"Biomarker research: Developing a blood cell-based diagnostic test with Raman microscope"},"content":{"rendered":"

ME\/CFS Biomarker is possible with Raman spectroscopy\u00a0<\/strong><\/h2>\n

 <\/p>\n

Researchers led by Prof Karl Morten in Oxford are confident they have found a suitable way of\u00a0distinguishing between healthy people, other diseases and ME\/CFS patients with high accuracy (91%), and can further differentiate between mild, moderate, and severe ME\/CFS patients (84%).<\/p>\n

\"\"Raman microscopes can detect altered levels of tryptophan and serotonin, together with decreased tyrosine levels in all disease groups and reduced phenylalanine in the severe ME group. Only a small amount of blood is needed.<\/p>\n

“Although the single-cell Raman spectroscopic approach is not yet readily available in certified diagnostic laboratories, which might represent a barrier to adoption, our study investigates its potential as a brand-new diagnostic technique that is rapid and minimally invasive thus allowing for more often longitudinal monitoring of the diseases.”<\/p>\n

The team is planning further research to validate these findings and invites people to donate<\/a>.<\/p>\n

 <\/p>\n

Developing a blood cell-based diagnostic test for Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome using peripheral blood mononuclear cells<\/a>, by Jiabao Xu, Tiffany Lodge, Caroline Kingdon, James W L Strong, John Maclennan, Eliana Lacerda, Slawomir Kujawski, Pawel Zalewski, Wei E Huang, Karl J Morten, in<\/span> Advanced Science<\/em>, 31 Aug 2023 [doi.org\/10.1002\/advs.202302146]<\/p>\n

Research abstract:<\/strong><\/h3>\n

Myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) is characterized by debilitating fatigue that profoundly impacts patients’ lives. Diagnosis of ME\/CFS remains challenging, with most patients relying on self-report, questionnaires, and subjective measures to receive a diagnosis, and many never receiving a clear diagnosis at all.<\/p>\n

In this study, a single-cell Raman platform<\/a> and artificial intelligence are utilized to analyze blood cells from 98 human subjects, including 61 ME\/CFS patients of varying disease severity and 37 healthy and disease controls.<\/p>\n

These results demonstrate that Raman profiles of blood cells can distinguish between healthy individuals, disease controls, and ME\/CFS patients with high accuracy (91%), and can further differentiate between mild, moderate, and severe ME\/CFS patients (84%).<\/p>\n

Additionally, specific Raman peaks that correlate with ME\/CFS phenotypes and have the potential to provide insights into biological changes and support the development of new therapeutics are identified. This study presents a promising approach for aiding in the diagnosis and management of ME\/CFS and can be extended to other unexplained chronic diseases such as long COVID and post-treatment Lyme disease syndrome, which share many of the same symptoms as ME\/CFS.<\/p>\n

Read more:<\/strong><\/h3>\n

Oxford University<\/strong>: Karl Morton<\/a><\/p>\n

Oxford University<\/strong>: Understanding the causes of ME\/CFS projects<\/a><\/p>\n

Health rising<\/strong>: A potential blood test for Chronic Fatigue Syndrome (ME\/CFS)?<\/a><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

ME\/CFS Biomarker is possible with Raman spectroscopy\u00a0   Researchers led by Prof Karl Morten in Oxford are confident they have found a suitable way of\u00a0distinguishing between healthy people, other diseases and ME\/CFS patients with high accuracy (91%), and can further … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":40681,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[],"class_list":["post-40666","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2023\/09\/Raman_microscope.jpg?fit=1280%2C709&ssl=1","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-azU","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/40666","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=40666"}],"version-history":[{"count":5,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/40666\/revisions"}],"predecessor-version":[{"id":40719,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/40666\/revisions\/40719"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media\/40681"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=40666"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=40666"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=40666"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}