{"id":41313,"date":"2023-11-02T08:40:40","date_gmt":"2023-11-02T08:40:40","guid":{"rendered":"https:\/\/wames.org.uk\/cms-english\/?p=41313"},"modified":"2023-11-02T08:40:40","modified_gmt":"2023-11-02T08:40:40","slug":"research-review-viral-infection-as-cause-of-me-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/research-review-viral-infection-as-cause-of-me-cfs\/","title":{"rendered":"Research review: Viral infection as cause of ME\/CFS"},"content":{"rendered":"

Viral infections found in people with ME\/CFS<\/strong><\/h2>\n

 <\/p>\n

\"\"Korean researchers searched the medical literature to find which viruses were associated with ME\/CFS.<\/p>\n

Borna disease virus (BDV), a viral disease of warm-blooded animals, notably horses and sheep, had the strongest links. Other viruses with links were: human herpes virus (HHV)-7, parvovirus B19 enterovirus and coxsackie B virus.<\/p>\n

Evaluation of viral infection as an etiology of ME\/CFS: a systematic review and meta-analysis<\/a> by Jae-Hyun Hwang, Jin-Seok Lee, Hyeon-Muk Oh, Eun-Jung Lee, Eun-Jin Lim, Chang-Gue Son in<\/span> J Transl Med<\/em>. 2023 Oct 28;21(1):763 [DOI: 10.1186\/s12967-023-04635-0]<\/p>\n

Review abstract<\/strong><\/p>\n

Background: <\/strong><\/p>\n

Myalgic encephalitis\/chronic fatigue syndrome (ME\/CFS) is a long-term disabling illness without a medically explained cause.<\/p>\n

Recently during COVID-19 pandemic, many studies have confirmed the symptoms similar to ME\/CFS in the recovered individuals. To investigate the virus-related etiopathogenesis<\/a> of ME\/CFS, we conducted a systematic assessment of viral infection frequency in ME\/CFS patients.<\/p>\n

Methods: <\/strong><\/p>\n

We conducted a comprehensive search of PubMed and the Cochrane Library from their inception through December 31, 2022, using selection criteria of viral infection prevalence in ME\/CFS patients and controls. Subsequently, we performed a meta-analysis to assess the extent of viral infections’ contribution to ME\/CFS by comparing the odds ratio between ME\/CFS patients and controls (healthy and\/or diseased).<\/p>\n

Results: <\/strong><\/p>\n

Finally, 64 studies met our eligibility criteria regarding 18 species of viruses, including a total of 4971 ME\/CFS patients and 9221 control subjects. The participants included healthy subjects and individuals with one of 10 diseases, such as multiple sclerosis or fibromyalgia.<\/p>\n

Two DNA viruses (human herpes virus (HHV)-7<\/a> and parvovirus B19<\/a>, including their co-infection) and 3 RNA viruses<\/a> (borna disease virus<\/a> (BDV), enterovirus<\/a> and coxsackie B virus<\/a>) showed odds ratios greater than 2.0 compared with healthy and\/or diseased subjects. Specifically, BDV exceeded the cutoff with an odds ratio of \u2265 3.47 (indicating a “moderate association” by Cohen’s d test<\/a>) compared to both healthy and diseased controls.<\/p>\n

Conclusion: <\/strong><\/p>\n

This study comprehensively evaluated the risk of viral infections associated with ME\/CFS, and identified BDV. These results provide valuable reference data for future studies investigating the role of viruses in the causation of ME\/CFS.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Viral infections found in people with ME\/CFS   Korean researchers searched the medical literature to find which viruses were associated with ME\/CFS. Borna disease virus (BDV), a viral disease of warm-blooded animals, notably horses and sheep, had the strongest links. … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[],"class_list":["post-41313","post","type-post","status-publish","format-standard","hentry","category-news"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-aKl","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/41313","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=41313"}],"version-history":[{"count":2,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/41313\/revisions"}],"predecessor-version":[{"id":41316,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/41313\/revisions\/41316"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=41313"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=41313"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=41313"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}