{"id":5818,"date":"2015-09-22T08:48:23","date_gmt":"2015-09-22T08:48:23","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=5818"},"modified":"2015-09-22T08:48:23","modified_gmt":"2015-09-22T08:48:23","slug":"low-nk-cell-activity-differs-in-mecfs-ms","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/low-nk-cell-activity-differs-in-mecfs-ms\/","title":{"rendered":"Low NK cell activity differs in ME\/CFS &#038; MS"},"content":{"rendered":"<h3>Research abstract:<\/h3>\n<p>Chronic Fatigue Syndrome\/Myalgic Encephalomyelitis (CFS\/ME) and <a href=\"http:\/\/www.nhs.uk\/conditions\/Multiple-sclerosis\/Pages\/Introduction.aspx\" target=\"_blank\">Multiple Sclerosis <\/a>(MS) patients suffer from debilitating fatigue which is not alleviated by rest. In addition to the fatigue related symptoms suffered by CFS\/ME and MS patients, dysfunction of the immune system and in particular, reduced <a href=\"https:\/\/en.wikipedia.org\/wiki\/Natural_killer_cell\" target=\"_blank\">Natural Killer (NK) cell <\/a>cytotoxic activity has also been reported in CFS\/ME and MS.<\/p>\n<p>The purpose of this pilot study was to compare NK cellular mechanisms in CFS\/ME and MS patients to investigate potential dysfunctions in the NK cell activity pathway. Flow cytometry protocols assessed CD56dim CD16+ and CD56bright CD16+\/- NK cell expression of adhesion molecules, NK activating and inhibiting receptors, NK cell maturation and lytic proteins.<\/p>\n<p>All participants in this study were female and included 14 CFS\/ME patients, 9 MS patients and 19 non-fatigued controls. The patient groups and the non-fatigued controls were not taking any immunosuppressive or immune enhancing medications.<\/p>\n<p>In the MS cohort, KIR2DL5 was significantly increased on CD56bright CD16+\/- NK cells and expression of CD94 was significantly increased on CD56dim CD16+ NK cells in comparison to the controls. Co-expression of CD57 and perforin was significantly increased on CD56dim CD16+ NK cells from CFS\/ME patients compared to the MS and non-fatigued control participants.<\/p>\n<p>The results from this pilot study suggest that NK cells from CFS\/ME and MS patients may have undergone increased differentiation in response to external stimuli which may affect different mechanisms in the NK cell cytotoxic activity pathway.<\/p>\n<p>Pilot Study of <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26381393\" target=\"_blank\">Natural Killer Cells in Chronic Fatigue Syndrome\/Myalgic Encephalomyelitis and Multiple Sclerosis,<\/a> by TK Huth, EW Brenu , S Ramos, T Nguyen, S Broadley, D Staines, S Marshall-Gradisnik\u00a0<span style=\"text-decoration: underline;\">in<\/span> <em>Scand J Immunol.<\/em> 2015 Sep 18.\u00a0 [Epub ahead of print]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research abstract: Chronic Fatigue Syndrome\/Myalgic Encephalomyelitis (CFS\/ME) and Multiple Sclerosis (MS) patients suffer from debilitating fatigue which is not alleviated by rest. In addition to the fatigue related symptoms suffered by CFS\/ME and MS patients, dysfunction of the immune system &hellip; <a href=\"https:\/\/wames.org.uk\/cms-english\/low-nk-cell-activity-differs-in-mecfs-ms\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[1249,661,556,783,722,691],"class_list":["post-5818","post","type-post","status-publish","format-standard","hentry","category-news","tag-dr-sonya-marshall-gradisnik","tag-immune-dysfunction","tag-ms","tag-multiple-sclerosis","tag-natural-killer-cells","tag-nk-cells"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-1vQ","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/5818","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=5818"}],"version-history":[{"count":2,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/5818\/revisions"}],"predecessor-version":[{"id":5821,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/5818\/revisions\/5821"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=5818"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=5818"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=5818"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}