BACKGROUND:
\nThere is evidence that Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS) is accompanied by gastro-intestinal symptoms; and IgA and IgM responses directed against lipopolysaccharides (LPS) of commensal bacteria, indicating bacterial translocation.<\/p>\n
METHODS:
\nThis study was carried out to examine gastro-intestinal symptoms in subjects with ME\/CFS versus those with chronic fatigue (CF). The two groups were dissected by dichotomizing those fulfilling and not fulfilling Fukuda’s critera. In these groups, we examined the association between gastro-intestinal symptoms and the IgA and IgM responses directed against commensal bacteria.<\/p>\n
RESULTS:
\nUsing cluster analysis performed on gastro-intestinal symptoms we delineated that the cluster analysis-generated diagnosis of abdominal discomfort syndrome (ADS) was significantly higher in subjects with ME\/CFS (59.6%) than in those with CF (17.7%). The diagnosis of ADS was strongly associated with the diagnosis of irritable bowel syndrome (IBS). There is evidence that ME\/CFS consists of two subgroups, i.e. ME\/CFS with and without ADS. Factor analysis showed four factors, i.e. 1) inflammation-hyperalgesia; 2) fatigue-malaise; 3) gastro-intestinal symptoms\/ADS; and 4) neurocognitive symptoms. The IgA and IgM responses to LPS of commensal bacteria were significantly higher in ME\/CFS patients with ADS than in those without ADS.<\/p>\n
CONCLUSIONS:
\nThe findings show that ADS is a characteristic of a subset of patients with ME\/CFS and that increased bacterial translocation (leaky gut) is associated with ADS symptoms. This study has defined a pathway phenotype, i.e bacterial translocation, that is related to ME\/CFS and ADS\/IBS and that may drive systemic inflammatory processes.<\/p>\n
Evidence for the existence of Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS) with and without abdominal discomfort (irritable bowel) syndrome.<\/a>\u00a0by M Research abstract: BACKGROUND: There is evidence that Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS) is accompanied by gastro-intestinal symptoms; and IgA and IgM responses directed against lipopolysaccharides (LPS) of commensal bacteria, indicating bacterial translocation. METHODS: This study was carried out to examine … Continue reading
\nMaes, J Leunis, M Geffard, M Berk in Neuro Endocrinol Lett<\/em>. 2014;35(6):445-53<\/p>\n","protected":false},"excerpt":{"rendered":"