{"id":9686,"date":"2016-09-02T06:24:54","date_gmt":"2016-09-02T06:24:54","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=9686"},"modified":"2016-09-02T06:24:54","modified_gmt":"2016-09-02T06:24:54","slug":"%ef%bb%bfmetabolomic-study-finds-amino-acid-deprivation-impacts-pain-in-mecfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/%ef%bb%bfmetabolomic-study-finds-amino-acid-deprivation-impacts-pain-in-mecfs\/","title":{"rendered":"\ufeffMetabolomic study finds amino acid deprivation impacts pain in ME\/CFS"},"content":{"rendered":"

ME Aus<\/strong>tralia blog post: Metabolomic study finds amino acid deprivation impacts pain<\/a>, by Sasha Nimmo, 1\u00a0September\u00a02016<\/p>\n

A team of Australian\u00a0scientists looked at\u00a0biochemistry changes connected with pain and kidney\u00a0function, identifying the biological basis of the development of widespread pain (July 2016).<\/p>\n

The paper\u2019s leading author is\u00a0Dr Neil McGregor<\/a>\u00a0from the University of Melbourne, who was profiled in \u2018Meet the Scientists\u2019.<\/p>\n

Dr McGregor explained that people with widepread pain lose amino acids through their kidney every time there is an increased inflammatory response and the frequent repetitive inflammatory response results in them gradually becoming depleted in amino acids.<\/p>\n

\u201cWidespread pain appears to be a consequence of the repeated inflammatory driven changes in renal concentrating activity leading to essential amino acid depletion.\u201d<\/p>\n

\u2018Widespread pain and renal function in MECFS<\/a>\u2018\u00a0is McGregor, Armstrong and Butt\u2019s third paper on metabolomics (noting that other scientists also worked on the papers), published in the July 2016 edition of\u00a0Fatigue: Biomedicine, Health & Behavior. \u00a0Here is a summary of their paper<\/a>\u00a0\u2018Metabolic profiling reveals anomalous energy metabolism and oxidative stress pathways in chronic fatigue syndrome patients\u2019.<\/p>\n

46\u00a0patients meeting the\u00a0Canadian Consensus\u00a0criteria (MECFS) were compared with 26\u00a0age and sex-matched healthy individuals. \u00a0They completed questionnaires and underwent a clinical examination, standard serum biochemistry, glucose tolerance tests and serum and urine metabolomes in an observational study.<\/p>\n

Interestingly, the paper says this study was designed to \u201cinvestigate metabolic changes in MECFS subjects using a discovery hypothesis and not a specific hypothesis driven method to assess specific biochemical events\u201d.<\/p>\n

The research found food intolerance, including cases of gluten intolerance, were associated with widespread pain.<\/p>\n

The paper said \u201cpossibly also involved would be insulin resistance mediated amino acid uptake as evidenced by the association with increasing blood glucose. The MECFS patients do have an anomaly in insulin excretion in this study (Data to be published separately) which supports this conclusion.\u201d<\/p>\n

\u201cResults: Increases in pain distribution were associated with reductions in serum essential amino acids, urea, serum sodium and increases in serum glucose and the 24-hour urine volume however the biochemistry was different for each pain area. Regression modelling revealed potential acetylation and methylation defects in the pain subjects.\u201d<\/p>\n

Dr McGregor said it was important to be able to reproduce findings to validate them and also gain greater insight into the issues.<\/p>\n

\u201cThis study has confirmed and extended the findings of our previous studies showing an association between altered amino acid excretion, urine volume, serum sodium, osmolality and increases in facial and widespread pain expression in MECFS patients.\u201d<\/p>\n

The team have upcoming\u00a0papers to be published which address the underlying biological issues involved in the process of post exertional fatigue\/malaise and its potential relationship to the exercise process.\u00a0Read more in\u00a0Dr McGregor\u2019s \u2018Meet the Scientist\u2019<\/a>.<\/p>\n

Also just released is the Open Medicine\u2019s \u2018Metabolic features of chronic fatigue syndrome\u2018 in which researchers claim to have discovered a metabolic signature.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

ME Australia blog post: Metabolomic study finds amino acid deprivation impacts pain, by Sasha Nimmo, 1\u00a0September\u00a02016 A team of Australian\u00a0scientists looked at\u00a0biochemistry changes connected with pain and kidney\u00a0function, identifying the biological basis of the development of widespread pain (July 2016). … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[3085,752,250,3084,1262,2904,2891],"class_list":["post-9686","post","type-post","status-publish","format-standard","hentry","category-news","tag-amino-acid-deprivation","tag-australia","tag-chronic-pain","tag-dr-neil-mcgregor","tag-metabolomics","tag-renal-dysfunction","tag-sasha-nimmo"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-2we","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/9686","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=9686"}],"version-history":[{"count":1,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/9686\/revisions"}],"predecessor-version":[{"id":9687,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/9686\/revisions\/9687"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=9686"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=9686"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=9686"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}