Review article abstract:

Chronic fatigue syndrome (CFS) is a debilitating and complex disorder characterized by profound fatigue with uncertain pathologic mechanism.

Neuroimage may be an important key to unveil the central nervous system (CNS) mechanism in CFS. Although most of the studies found gray matter (GM) volumes reduced in some brain regions in CFS, there are many factors that could affect GM volumes in CFS, including chronic pain, stress, psychiatric disorder, physical activity, and insomnia, which may bias the results. In this paper, through reviewing recent literatures, we discussed these interferential factors, which overlap with the symptoms of CFS.

Gray Matter Volumes in Patients with Chronic Fatigue Syndrome, by Le-wei Tang, Hui Zheng, Liang Chen, Si-yuan Zhou, Wen-jing Huang, Ying Li, and Xi Wu in Evidence-Based Complementary and Alternative Medicine, Volume 2015, Article ID 380615, 7 pages  [Accepted 26 August 2014]
http://dx.doi.org/10.1155/2015/380615