Tag Archives: Central Nervous System

Advances in understanding the pathophysiology of CFS

Advances in understanding the pathophysiology of Chronic Fatigue Syndrome, by Anthony L Komaroff in JAMA [Preprint July 5, 2019]   Viewpoint extracts: When does an illness become a disease? When the underlying biological abnormalities that cause the symptoms and signs of the … Continue reading

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The putative glymphatic signature of CFS

The putative glymphatic signature of CFS: A new view on the disease pathogenesis and therapy, by Peter Wostyn, Peter Paul De Deyn in Medical Hypotheses Sept 2018, Vol 118, Pages 142–145 Abstract: The underlying pathophysiology of chronic fatigue syndrome remains incompletely understood and there … Continue reading

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Cortical hypoactivation during resting EEG suggests central nervous system pathology in patients with CFS

Research abstract: Cortical hypoactivation during resting EEG suggests central nervous system pathology in patients with chronic fatigue syndrome, by MA Zinn, ML Zinna, I Valencia, LA Jason, JG Montoya in Biological Psychology Vol 136, July 2018, Pages 87-99 We investigated central fatigue in 50 patients … Continue reading

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Transient Receptor Potential Ion channels in the etiology & pathomechanism of CFS/ME

Research abstract: Transient Receptor Potential Ion Channels in the Etiology and Pathomechanism of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, by Donald Staines, S Du Preez, H Cabanas, C Balinas, N Eaton, R Passmore, R Maksoud, J Redmayne, S Marshall-Gradisnik in  International Journal … Continue reading

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Glial cell inhibitors: the next sleep drugs for FM and ME/CFS?

Health Rising blog post, by Cort Johnson, 15 September: Glial Cell Inhibitors: The Next Sleep Drugs for Fibromyalgia and Chronic Fatigue Syndrome (ME/CFS)?   Glia: The Forgotten Brain Cell Sleep disturbances and severe stress as glial activators: key targets for … Continue reading

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Inflammation correlates with symptoms in CFS

Research overview abstract: Inflammation correlates with symptoms in chronic fatigue syndrome, by Anthony L Komaroff in PNAS August 15, 2017 It is not unusual for patients who say they are sick to have normal results on standard laboratory testing. The physician … Continue reading

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Central nervous system findings in CFS

Review abstract: CNS findings in chronic fatigue syndrome and a neuropathological case report Kimberly Ferrero, Mitchell Silver, Alan Cocchetto, Eliezer Masliah, Dianne Langford in Journal of Investigative Medicine Vol 65 Issue 4 [published 6 April 2017] Chronic fatigue syndrome (CFS) is characterized as a persistent, debilitating complex disorder of unknown … Continue reading

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ME/CFS studies link autonomic nervous system problems to brain

Health rising blog post, by Cort Johnson, 3 Feb 2017: Chronic Fatigue Syndrome Studies Link Autonomic Nervous System Problems to Brain Dr. Barnden of the National Centre for NeuroImmnology and Emerging Diseases (NCNED) in Griffith University, Australia has been doing … Continue reading

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Roles of the right dorsolateral prefrontal cortex during physical fatigue: a magnetoencephalographic study

Research abstract: Background: A regulation system in the central nervous system plays an important role in controlling physical performance during physical fatigue. Purpose: To clarify the neural mechanisms of this regulation system during physical fatigue using magnetoencephalography (MEG) and a … Continue reading

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Immune activation in the central nervous system of ME/CFS found by cytokine network analysis of cerebrospinal fluid

Research abstract: Myalgic encephalomyelitis/chronic fatigue syndrome is an unexplained debilitating disorder that is frequently associated with cognitive and motor dysfunction. We analyzed cerebrospinal fluid from 32 cases, 40 subjects with multiple sclerosis and 19 normal subjects frequency-matched for age and … Continue reading

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