Research led by Prof Komaroff from Harvard Medical School found that unmedicated CFS patients could be distinguished from patients with depression, though more research is needed before EEG can be used as a diagnostic tool.
Conclusions:
EEG spectral coherence analysis identified unmedicated patients with CFS and healthy control subjects without misclassifying depressed patients as CFS, providing evidence that CFS patients demonstrate brain physiology that is not observed in healthy normals or patients with major depression. Studies of new CFS patients and comparison groups are required to determine the possible clinical utility of this test. The results concur with other studies finding neurological abnormalities in CFS, and implicate temporal lobe involvement in CFS pathophysiology.
