Abstract:

Stimulant drugs and various micronutrient interventions have previously been studied in chronic fatigue syndrome (CFS) but they have never been studied in combination.

This proof of concept investigation seeks to examine the clinical effects and safety profile of KPAX002 (a combination of methylphenidate hydrochloride (Ritalin) and mitochondrial support nutrients) in patients with CFS.

Fifteen patients diagnosed with CFS by 1994 Fukuda criteria were recruited and treated with KPAX002 to explore a potential synergistic effect of this combination. Fatigue and
concentration disturbance symptoms were measured at baseline, 4 weeks, and 12 weeks using two clinically validated tools: Checklist Individual Strength (CIS) and Visual Analog Scale (VAS).

The primary outcome objective was a decrease in the total CIS score of ≥25% in at least 50% of the subjects. The mean total CIS score decreased by 36.4 points (34%) at 12 weeks (P<0.0001), corresponding to a ≥25% decrease in 87% of the participants.

Treatment with KPAX002 was well tolerated and significantly improved fatigue and concentration disturbance symptoms in greater than 50% of patients with CFS. These results were statistically significant. This combination treatment is worthy of additional investigation.

A prospective, proof-of-concept investigation of KPAX002 in chronic fatigue syndrome, by Jon D Kaiser in Int J Clin Exp Med, 2015; 8(7): 11064-11074. [Received May 21, 2015; Accepted July 11, 2015; Epub July 15, 2015; Published July 30, 2015]

Cort Johnson in in Health rising examines the unusual placebo results in this KPax Synergy trial, what the improvement in symptoms meant for some of the participants, the role of the micronutrients and possible future trials.

Synergizing Health? The K Pax Chronic Fatigue Syndrome Study Results are In…, by Cort Johnson on May 8, 2015