Diagnostic Guidelines


Detailed guidance on the diagnosis of ME can be  obtained from:

BMJ Best clinical practice

Updated information from Sep 2018 on the theory, diagnosis, management, follow up and resources for Chronic fatigue syndrome/ myalgic encephalomyelitis. Access through your NHS Open Athens account or request a free trial.

NICE2007 UK guidance now undergoing a major review

due to concerns about the recommended treatment

ME Association: ME/CFS/PVFS: an exploration of the key clinical issues

the ‘purple book’ is updated annually by UK GP Dr Charles Shepherd and neurologist Abhijit Chaudhuri. (Health professionals can contact the MEA for a free copy.)

Myalgic Encephalomyelitis – adult and pediatric: International Consensus Primer for medical practitioners

The 2011 International Consensus Primer covers criteria, pathophysiology, and diagnostic and treatment protocols and is a later development of the widely accepted Canadian criteria: Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome: A Clinical Case Definition and Guidelines for Medical Practitioners (2005)

Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness

A 2015 US report giving a clinician’s guide, diagnostic algorithm and diagnostic criteria.

Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome: Diagnosis and management in young people: a primer (2017)

Although paediatric ME overlaps with adult ME this paediatric primer was developed to cover the many unique aspects of the diagnosis and management of paediatric ME/CFS.


See also videos giving an overview of ME/CFS: Diagnosis – an introduction

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