Tag Archives: exercise intolerance

Characteristics of CFS/ME sub-group who respond to Rintatolimod (Ampligen)

Posted on 09/29/2015 by wames

Research abstract: Background: Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a debilitating disease of unknown pathogenesis consisting of  a variety of flu-like symptoms including severe fatigue. Initial analysis of the use of rintatolimod (Poly I: Poly C12U), a selective TLR3 agonist, … Continue reading →

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Computer simulation explores cause for exercise intolerance in ME/CFS

Posted on 04/17/2015 by wames

Research abstract: Post-exertional malaise is commonly observed in patients with myalgic encephalomyelitis/chronic fatigue syndrome, but its mechanism is not yet well understood. A reduced capacity for mitochondrial ATP synthesis is associated with the pathogenesis of CFS and is suspected to … Continue reading →

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Evidence found for sensitised fatigue pathways in CFS

Posted on 02/18/2015 by wames

Research abstract: Patients with Chronic Fatigue Syndrome (CFS) frequently demonstrate intolerance to physical exertion that is often reported as increased and long-lasting fatigue. As no specific metabolic alterations have been identified in CFS patients we hypothesized that sensitized fatigue pathways … Continue reading →

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Repeated exercise tests have role as diagnostic test for ME/CFS

Posted on 04/23/2014 by wames

Abstract (provisional) Background Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a multi-system illness characterized, in part, by increased fatigue following minimal exertion, cognitive impairment, poor recovery to physical and other stressors, in addition to other symptoms. Unlike healthy subjects and other … Continue reading →

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Exercise intolerance in CFS caused by low oxygen extraction

Posted on 03/11/2014 by wames

Abstract Background: The insufficient metabolic adaptation to exercise in Chronic Fatigue Syndrome (CFS) is still being debated and poorly understood. Methods: We analysed the cardiopulmonary exercise tests of CFS patients, idiopathic chronic fatigue (CFI) patients and healthy visitors. Continuous non-invasive … Continue reading →

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Low oxygen uptake by muscle cells causes exercise intolerance

Posted on 01/26/2014 by wames

Abstract Background The insufficient metabolic adaptation to exercise in Chronic Fatigue Syndrome (CFS) is still being debated and poorly understood. Methods We analysed the cardiopulmonary exercise tests of CFS patients, idiopathic chronic fatigue (CFI) patients and healthy visitors. Continuous non-invasive … Continue reading →

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Ampligen trial shows benefits for long-standing debilitating CFS

Posted on 03/18/2012 by wames

A major study on the effects of Ampligen (Rintatolimod) on CFS  provides added proof of Ampligen’s efficacy in ME/CFS following America’s Food & Drug Administration’s refusal to approve Ampligen for CFS in Dec 2009. 234 subjects with long-standing, debilitating CFS … Continue reading →

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