shoutoutaboutme blog post, by Russell Logan, 31 July 2016: 9 potential diagnostic tests for ME/CFS: Highlights of the IACFS submission to NIH RFI on new research strategies

Though there are as yet no readily available, well-accepted, objective diagnostic tests for ME and CFS, work is ongoing in several key areas to develop one.

One objective measure, the 2-day CPET, is gaining acceptance and has been used with success in legal presentations. A drawback to this measure is its potential for harming patients.

And there are good subjective or self-reported diagnostic measures, though these are of limited value in clinical diagnosis.

In its response to the recent NIH solicitation for input into new research strategies for ME/CFS, the International Association for Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis (IACFS/ME) documented emerging opportunities, research needs, and continuing challenges, but in particular highlighted promising work on developing a diagostic test or biological marker for the illness.

The IACFS/ME authors — Lily Chu, Fred Friedberg, Staci Stevens,  Steve Krafchick, and Jon Kaiser — noted: “Some tests might not be suitable for clinical use but might provide a gold standard test for research purposes [and] may also provide clues to the pathophysiology of this disease and even to future treatments.”

“They identified 9 key areas of investigation requiring urgent need of government support and funding.”

Read more about these key areas of investigation into testing for ME and CFS.

  • LOW NATURAL KILLER CELL ACTIVITY
  • 2-DAY REPEATED CARDIOPULMONARY EXERCISE TESTING
  • NEUROPSYCHOLOGICAL TESTING RELATED TO INFORMATION PROCESSING
  • TILT TABLE TESTING
  • NEUROINFLAMMATION
  • UNREFRESHING SLEEP, HEART RATE VARIABILITY, AND SYMPATHETIC PREDOMINANCE
  • FAMILIAL STUDIES
  • ENERGY METABOLISM ISSUES AND LACTATE PROCESSING IN MUSCLE AND BRAIN
  • POST-INFECTIOUS TRIGGERS
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