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Neural consequences of PEM in ME/CFS
Research abstract: Highlights: Acute exercise affects symptoms, cognitive performance and brain function in ME/CFS. Symptom provocation by exercise is a useful model to study post-exertion malaise. Objective neurophysiological evidence of the phenomenon of post-exertion malaise. Post exertion malaise is one … Continue reading
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Tagged Alan R Light, brain dysfunction, cognitive dysfunction, Dr Dane B Cook, Dr Suzanne Vernon, fMRI, Kathleen C Light, PEM, Post-exertional malaise
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The Brain Initiative: FM & ME/CFS perspective
Health rising blog post, by Cort Johnson, 8 Jan 2017: The Brain Initiative: a Fibromyalgia and Chronic Fatigue Syndrome (ME/CFS) perspective In the third of three blogs looking at the research efforts of tomorrow and their potential impact on fibromyalgia and … Continue reading
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Tagged brain, Brain Initiative, Cort Johnson, fMRI, National Institutes of Health, NIH, TMS, ultrasounds
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Brain scan shows altered connectivity between different regions of the brain in CFS
Research abstract: Studies using arterial spin labelling (ASL) have shown that individuals with chronic fatigue syndrome (CFS) have decreased regional cerebral blood flow, which may be associated with changes in functional neural networks. Indeed, recent studies indicate disruptions in functional … Continue reading
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Tagged brain dysfunction, fMRI, Functional connectivity
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Altered neural networks in adolescent CFS
Research abstract: Neural network investigations are currently absent in adolescent chronic fatigue syndrome (CFS). In this study, we examine whether the core intrinsic connectivity networks (ICNs) are altered in adolescent CFS patients. Eighteen adolescent patients with CFS and 18 aged … Continue reading
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Tagged adolescents, brain, fMRI, functional magnetic resonance imaging, insula dysfunction, neural networks, teenagers
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Fatigue may involve abnormal function of the motor system
Research abstract: Although the prevalence of chronic fatigue is approximately 20% in healthy individuals, there are no studies of brain structure that elucidate the neural correlates of fatigue outside of clinical subjects. We hypothesized that fatigue without evidence of disease … Continue reading
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Tagged basal ganglia, brain, chronic fatigue, fMRI, motor system, white matter
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Abnormal cerebral blood flow found in ME/CFS by ASL fMRI
Research abstract: BACKGROUND Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disorder characterized by severe fatigue and neurocognitive dysfunction. Recent work from our laboratory and others utilizing arterial spin labeling functional magnetic resonance imaging (ASL) indicated that ME/CFS patients have … Continue reading
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Tagged arterial spin labeling, ASL, cerebral blood flow, fMRI, functional magnetic resonance imaging, rCBF, resting state regional cerebral blood flow
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Abnormal brain activity found in women with CFS
Research abstract: The biological underpinnings of the psychological factors characterizing chronic fatigue syndrome (CFS) have not been extensively studied. Our aim was to evaluate alterations of resting-state functional connectivity in CFS patients. Participants comprised 18 women with CFS and 18 … Continue reading
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Tagged altered resting-state connectivity, fMRI, functional magnetic resonance imaging
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The brain’s frontal cortex works inefficiently in children with CFS
Research abstract: The ability to divide one’s attention deteriorates in patients with childhood chronic fatigue syndrome (CCFS). We conducted a study using a dual verbal task to assess allocation of attentional resources to two simultaneous activities (picking out vowels and … Continue reading
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Tagged adolescents, children, cognitive effort, fMRI, frontal cortex, functional magnetic resonance imaging, teenagers
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Abnormal blood flow & connectivity found in ME/CFS brains
Research abstract: Although altered resting-state functional connectivity is a characteristic of many chronic pain conditions it has not yet been evaluated in patients with chronic fatigue. Our objective was to investigate the association between fatigue and altered resting-state functional connectivity … Continue reading
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Tagged brain dysfunction, cerebral blood flow, fMRI, Functional connectivity
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Children with CFS use more of their brain to concentrate
Research abstract: The ability to divide one’s attention deteriorates in patients with childhood chronic fatigue syndrome (CCFS). We conducted a study using a dual verbal task to assess allocation of attentional resources to two simultaneous activities (picking out vowels and … Continue reading
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Tagged adolescents, brain, children, concentration, energy, fMRI, frontal cortex, functional magnetic resonance imaging, teenagers, young people
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