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Research: Muscle sodium overload in patients with ME/CFS
Muscle sodium content in patients with ME/CFS A German team of researchers used magnetic resonance imaging (MRI) to measure levels of sodium in the tissues of the legs of people with ME/CFS and healthy people. Too much sodium can … Continue reading
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Tagged 23Na-MRI, Carmen Scheibenbogen, Christian Stehning, Dr Katrina Pearce, Elisabeth Petter, Klaus J Wirth, Marcus Kelm, MRI, muscle fatigue, Peter Linz, sodium overload, Titus Kuehne
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Pathophysiology of skeletal muscle disturbances in ME/CFS
Pathophysiology of skeletal muscle disturbances in Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS), by Klaus J Wirth & Carmen Scheibenbogen in Journal of Translational Medicine vol 19, no. 162 (2021) [doi.org/10.1186/s12967-021-02833-2] Review abstract: Chronic Fatigue Syndrome or Myalgic Encephaloymelitis (ME/CFS) … Continue reading
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Tagged abnormal blood circulation, Carmen Scheibenbogen, Klaus J Wirth, muscle fatigue, Na+/K+-ATPase, Post-exertional malaise, sodium overload, ß2-adrenergic receptor dysfunction, ß2AdR, vascular dysfunction
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Post-exertional malaise: an exploratory factor analysis
Research abstract: Post-exertional malaise is a cardinal symptom of myalgic encephalomyelitis and chronic fatigue syndrome. There are two differing focuses when defining post-exertional malaise: a generalized, full-body fatigue and a muscle-specific fatigue. This study aimed to discern whether post-exertional malaise … Continue reading
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Tagged chronic fatigue, exploratory factor analysis, Madison L Sunnquist, muscle fatigue, PEM, Post-exertional malaise, Prof Leonard Jason, Stephanie L McManimen
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Muscle cell abnormalities in CFS: AMPK & IL6
Research abstract: Background: Post exertional muscle fatigue is a key feature in Chronic Fatigue Syndrome (CFS). Abnormalities of skeletal muscle function have been identified in some but not all patients with CFS. To try to limit potential confounders that might … Continue reading
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Tagged AMPK, electrical pulse stimulation, epigenetic mechanism, EPS, IL6, interleukin-6, muscle cells, muscle fatigue
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CFS subgroup found to have low level inflammation
CFS is characterized by profound levels of persistent/recurrent fatigue. It is proposed that chronic, low level inflammation may play a role in this fatigue. We recruited 100 untreated patients with CFS (average age 33±12) and 100 age and sex matched … Continue reading
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Tagged cytokines, inflammation, mitochondrial dysfunction, muscle fatigue
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