Tag Archives: mitochondrial dysfunction

MtDNA population variation in ME/CFS in two populations

MtDNA population variation in Myalgic encephalomyelitis/ Chronic fatigue syndrome in two populations: a study of mildly deleterious variants, by Marianne Venter, Cara Tomas, Ilse S Pienaar, Victoria Strassheim, Elardus Erasmus, Wan-Fai Ng, Neil Howell, Julia L Newton, Francois H Van … Continue reading

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Changes in the transcriptome of circulating immune cells of a N Z cohort with ME/CFS

Changes in the transcriptome of circulating immune cells of a New Zealand cohort with myalgic encephalomyelitis/chronic fatigue syndrome, by Eiren Sweetman, Margaret Ryan, Christina Edgar, Angus MacKay, Rosamund Vallings, Warren Tate in International Journal of Immunopathology and Pharmacology vol 33 2019 [Published … Continue reading

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A new approach to find biomarkers in CFS/ME by single-cell Raman micro-spectroscopy

A new approach to find biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) by single-cell Raman micro-spectroscopy, by Jiabao Xu,  Michelle Potter,  Cara Tomas,  Jo Elson,  Karl Morten,  Joanna Poulton,  Ning Wang, Hanqing Jin,  Zhaoxu Hou and Wei Huang in Analyst 2018 [published 22Aug 2018] Research abstract: Chronic fatigue syndrome … Continue reading

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KPAX002 as a treatment for ME/CFS – disappointing trial results

  Research abstract: KPAX002 as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a prospective, randomized trial, by Jose G Montoya, Jill N Anderson, Danya L Adolphs, Lucinda Bateman, Nancy Klimas, Susan M Levine, Donn W Garvert, Jon D Kaiser … Continue reading

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Review of potential causes of muscle dysfunction in ME/CFS

Review abstract: Purpose of Review: Here, we review potential causes of muscle dysfunction seen in many patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) such as the effects of oxidative and nitrosative stress (O&NS) and mitochondrial impairments together with reduced heat … Continue reading

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Myhill & McLaren-Howard discuss apparent contradictions in mitochondria research

DoctorMyhill.co.uk article, by Dr Sarah Myhill & John Howard-McLaren-Howard, 11 January 2017: Reply to Lawson Paper Background: In 2016, Nick Lawson, Chung-Han Hsieh, Dana March, Xinnan Wang published a paper with the title “Elevated Energy Production in Chronic Fatigue Syndrome … Continue reading

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Elevated energy production by non-mitochondrial sources in CFS sub-group

Research abstract: Chronic Fatigue Syndrome (CFS) is a debilitating disease characterized by physical and mental exhaustion. The underlying pathogenesis is unknown, but impairments in certain mitochondrial functions have been found in some CFS patients. To thoroughly reveal mitochondrial deficiencies in … Continue reading

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Prof Garth Nicolson’s research: ME & restoring mitochondrial functioning

Prof. Garth Nicolson introduces his research: We have been involved in research on the role of mitochondrial function in ME/CFS for some time and have found that restoring inner mitochondrial membrane (IMM) trans-membrane potential is essential. When mitochondrial membrane lipids are damaged, the IMM becomes … Continue reading

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A new approach for investigating mitochondrial DNA in ME

Research abstract: In mitochondrial research, many investigators have examined the association between mitochondrial DNA (mtDNA) variants in rare as well as common complex diseases. Previous studies at the CHM (NWU) detected three known pathogenic mtDNA variants (m.7497G>A, m.9185T>C and m.10197G>A) at … Continue reading

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More in-depth mitochondrial testing in ME/CFS proposed

Blog post by Cort Johnson in Health Rising forum, 20 June 2016: Researchers Call For More In-depth Mitochondrial Testing in Chronic Fatigue Syndrome (ME/CFS) More Extensive Mitochondrial Testing Proposed A letter to the editor of the BioMed Central Journal urged … Continue reading

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