Tag Archives: hypothalamic-pituitary-adrenal axis hypofunction

Hypothalamic-Pituitary-Adrenal Hypofunction in ME/CFS

Posted on 11/09/2016 by wames

Review abstract: There is evidence that immune-inflammatory and oxidative and nitrosative stress (O&NS) pathways play a role in the pathophysiology of myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS). There is also evidence that these neuroimmune diseases are accompanied by hypothalamic-pituitary-adrenal (HPA) axis … Continue reading →

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Childhood trauma did not increase changes to DNA in women with CFS

Posted on 09/10/2015 by wames

Research abstract: OBJECTIVES: Chronic fatigue syndrome (CFS) has been associated with hypothalamic-pituitary-adrenal axis hypofunction and enhanced glucocorticoid receptor (GR) sensitivity. In addition, childhood trauma is considered a major risk factor for the syndrome. This study examines DNA methylation of the … Continue reading →

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Hypocortisolism in CFS adolescents responds to treatment

Posted on 04/27/2014 by wames

Abstract BACKGROUND: There is accumulating evidence of hypothalamic-pituitary-adrenal (HPA) axis hypofunction in chronic fatigue syndrome (CFS). However, knowledge of this hypofunction has so far come exclusively from research in adulthood, and its clinical significance remains unclear. The objective of the … Continue reading →

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