Tag Archives: Gerwyn Morris

Is a diagnostic blood test for CFS on the horizon?

Is a diagnostic blood test for chronic fatigue syndrome on the horizon?, by Michael Maes, Laura Andres & Gerwyn Morris in Expert Review of Molecular Diagnostics, Published online: 18 Oct 2019 [https://doi.org/10.1080/14737159.2020.1681976]   Expert opinion Most if not all biomarkers of … Continue reading

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ME/CFS: From pathophysiological insights to novel therapeutic opportunities

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: from pathophysiological insights to novel therapeutic opportunities, by Gerwyn Morris, Basant K Puri, Adam J Walker, Michael Maes, Andre F Carvalho, Ken Walder, Catherine Mazza, Michael Berk in Pharmacological Research [Available online 8 September 2019] https://doi.org/10.1016/j.phrs.2019.104450 … Continue reading

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Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?

Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?, by Gerwyn Morris, Michael Maes, Michael Berk, Basant K. Puri in Metabolic Brain Disease pp 1–31 [Online: 13 February Review article abstract: A model of the development and progression of chronic fatigue syndrome (myalgic encephalomyelitis), … Continue reading

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A comparison of neuroimaging abnormalities in MS, Depression & CFS (ME)

Article abstract: A Comparison of Neuroimaging Abnormalities in Multiple Sclerosis, Major Depression and Chronic Fatigue Syndrome (Myalgic Encephalomyelitis): is There a Common Cause?, by Gerwyn Morris, Michael Berk, Basant K Puri in Mol Neurobiol. pp 1-18 [Published online 17 May … Continue reading

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Review of potential causes of muscle dysfunction in ME/CFS

Review abstract: Purpose of Review: Here, we review potential causes of muscle dysfunction seen in many patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) such as the effects of oxidative and nitrosative stress (O&NS) and mitochondrial impairments together with reduced heat … Continue reading

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Hypothalamic-Pituitary-Adrenal Hypofunction in ME/CFS

Review abstract: There is evidence that immune-inflammatory and oxidative and nitrosative stress (O&NS) pathways play a role in the pathophysiology of myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS). There is also evidence that these neuroimmune diseases are accompanied by hypothalamic-pituitary-adrenal (HPA) axis … Continue reading

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TRYCATS in CFS, Alzheimer’s disease and schizophrenia

Article abstract: Many if not all chronic medical, neurodegenerative and neuroprogressive illnesses are characterised by chronic immune activation, oxidative and nitrosative stress (O&NS) and systemic inflammation. These environmental factors notably elevated pro-inflammatory cytokines activate indoleamine 2,3-dioxygenase (IDO) leading to an upregulated … Continue reading

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The role of infections & moulds in chronic fatigue

Abstract Patients who present with severe intractable apparently idiopathic fatigue accompanied by profound physical and or cognitive disability present a significant therapeutic challenge. The effect of psychological counseling is limited, with significant but very slight improvements in psychometric measures of … Continue reading

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Possible causes of mitochondrial dysfunctions in ME

Abstract Myalgic encephalomyelitis / chronic fatigue syndrome (ME/cfs) is classified by the World Health Organization as a disorder of the central nervous system. ME/cfs is an neuro-immune disorder accompanied by chronic low-grade inflammation, increased levels of oxidative and nitrosative stress … Continue reading

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A strategy for defining and distinguishing ME & CFS

 Abstract The symptom spectrum of Myalgic Encephalomyelitis (ME) was first detailed in 1959 and later operationalised into a diagnostic protocol (Melvin Ramsey). In 1988 the Holmes case definition coined the term chronic fatigue syndrome (CFS). Fukuda’s Centers for Disease Control … Continue reading

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