Tag Archives: Michael Maes

Mitochondria & immunity in CFS

Mitochondria and Immunity in Chronic Fatigue Syndrome, by G Anderson, Michael Maes in Prog Neuropsychopharmacol Biol Psychiatry 2020 May 26 [DOI:10.1016/j.pnpbp.2020.109976]   Review abstract: It is widely accepted that the pathophysiology and treatment of myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS) … Continue reading

Posted in News | Tagged , , , , , | Comments Off on Mitochondria & immunity in CFS

Environmental, neuro-immune & neuro-oxidative stress interactions in CFS

Environmental, neuro-immune, and neuro-oxidative stress interactions in Chronic Fatigue Syndrome, by Geir Bjørklund, Maryam Dadar, Lyudmila Pivina, Monica Daniela Doşa, Yuliya Semenova & Michael Maes in Molecular Neurobiology (2020) [doi.org/10.1007/s12035-020-01939-w]   Review abstract: Chronic fatigue syndrome/myalgic encephalomyelitis (CFS) is a complex, … Continue reading

Posted in News | Tagged , , , , , , , , , , , , | Comments Off on Environmental, neuro-immune & neuro-oxidative stress interactions in CFS

Is a diagnostic blood test for CFS on the horizon?

Is a diagnostic blood test for chronic fatigue syndrome on the horizon?, by Michael Maes, Laura Andres & Gerwyn Morris in Expert Review of Molecular Diagnostics, Published online: 18 Oct 2019 [https://doi.org/10.1080/14737159.2020.1681976]   Expert opinion Most if not all biomarkers of … Continue reading

Posted in News | Tagged , , , , , | Comments Off on Is a diagnostic blood test for CFS on the horizon?

Shared microglial mechanisms underpinning depression & CFS & their comorbidities

Shared microglial mechanisms underpinning depression and chronic fatigue syndrome and their comorbidities, by Adriano José Maia Chaves-Filho, Danielle S Macedo, David Freitas de Lucena, Michael Maes in Behavioural Brain Research Vol 372, 17 October 2019, 111975 [https://doi.org/10.1016/j.bbr.2019.111975]   Research abstract: … Continue reading

Posted in News | Tagged , , , , , , , , | Comments Off on Shared microglial mechanisms underpinning depression & CFS & their comorbidities

ME/CFS: From pathophysiological insights to novel therapeutic opportunities

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: from pathophysiological insights to novel therapeutic opportunities, by Gerwyn Morris, Basant K Puri, Adam J Walker, Michael Maes, Andre F Carvalho, Ken Walder, Catherine Mazza, Michael Berk in Pharmacological Research [Available online 8 September 2019] https://doi.org/10.1016/j.phrs.2019.104450 … Continue reading

Posted in News | Tagged , , , , , , , , , , , , , | Comments Off on ME/CFS: From pathophysiological insights to novel therapeutic opportunities

Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?

Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?, by Gerwyn Morris, Michael Maes, Michael Berk, Basant K. Puri in Metabolic Brain Disease pp 1–31 [Online: 13 February Review article abstract: A model of the development and progression of chronic fatigue syndrome (myalgic encephalomyelitis), … Continue reading

Posted in News | Tagged , , , , , , , | Comments Off on Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?

Review of potential causes of muscle dysfunction in ME/CFS

Review abstract: Purpose of Review: Here, we review potential causes of muscle dysfunction seen in many patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) such as the effects of oxidative and nitrosative stress (O&NS) and mitochondrial impairments together with reduced heat … Continue reading

Posted in News | Tagged , , , , | Comments Off on Review of potential causes of muscle dysfunction in ME/CFS

Hypothalamic-Pituitary-Adrenal Hypofunction in ME/CFS

Review abstract: There is evidence that immune-inflammatory and oxidative and nitrosative stress (O&NS) pathways play a role in the pathophysiology of myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS). There is also evidence that these neuroimmune diseases are accompanied by hypothalamic-pituitary-adrenal (HPA) axis … Continue reading

Posted in News | Tagged , , , , , , , | Comments Off on Hypothalamic-Pituitary-Adrenal Hypofunction in ME/CFS

A subset of ME/CFS patients have IBS

Research abstract: BACKGROUND: There is evidence that Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is accompanied by gastro-intestinal symptoms; and IgA and IgM responses directed against lipopolysaccharides (LPS) of commensal bacteria, indicating bacterial translocation. METHODS: This study was carried out to examine … Continue reading

Posted in News | Tagged , , , , , , , | Comments Off on A subset of ME/CFS patients have IBS

TRYCATS in CFS, Alzheimer’s disease and schizophrenia

Article abstract: Many if not all chronic medical, neurodegenerative and neuroprogressive illnesses are characterised by chronic immune activation, oxidative and nitrosative stress (O&NS) and systemic inflammation. These environmental factors notably elevated pro-inflammatory cytokines activate indoleamine 2,3-dioxygenase (IDO) leading to an upregulated … Continue reading

Posted in News | Tagged , , , , , , , , | Comments Off on TRYCATS in CFS, Alzheimer’s disease and schizophrenia