Tag Archives: Michael Maes

Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?

Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?, by Gerwyn Morris, Michael Maes, Michael Berk, Basant K. Puri in Metabolic Brain Disease pp 1–31 [Online: 13 February Review article abstract: A model of the development and progression of chronic fatigue syndrome (myalgic encephalomyelitis), … Continue reading

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Review of potential causes of muscle dysfunction in ME/CFS

Review abstract: Purpose of Review: Here, we review potential causes of muscle dysfunction seen in many patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) such as the effects of oxidative and nitrosative stress (O&NS) and mitochondrial impairments together with reduced heat … Continue reading

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Hypothalamic-Pituitary-Adrenal Hypofunction in ME/CFS

Review abstract: There is evidence that immune-inflammatory and oxidative and nitrosative stress (O&NS) pathways play a role in the pathophysiology of myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS). There is also evidence that these neuroimmune diseases are accompanied by hypothalamic-pituitary-adrenal (HPA) axis … Continue reading

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A subset of ME/CFS patients have IBS

Research abstract: BACKGROUND: There is evidence that Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is accompanied by gastro-intestinal symptoms; and IgA and IgM responses directed against lipopolysaccharides (LPS) of commensal bacteria, indicating bacterial translocation. METHODS: This study was carried out to examine … Continue reading

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TRYCATS in CFS, Alzheimer’s disease and schizophrenia

Article abstract: Many if not all chronic medical, neurodegenerative and neuroprogressive illnesses are characterised by chronic immune activation, oxidative and nitrosative stress (O&NS) and systemic inflammation. These environmental factors notably elevated pro-inflammatory cytokines activate indoleamine 2,3-dioxygenase (IDO) leading to an upregulated … Continue reading

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The role of infections & moulds in chronic fatigue

Abstract Patients who present with severe intractable apparently idiopathic fatigue accompanied by profound physical and or cognitive disability present a significant therapeutic challenge. The effect of psychological counseling is limited, with significant but very slight improvements in psychometric measures of … Continue reading

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Possible causes of mitochondrial dysfunctions in ME

Abstract Myalgic encephalomyelitis / chronic fatigue syndrome (ME/cfs) is classified by the World Health Organization as a disorder of the central nervous system. ME/cfs is an neuro-immune disorder accompanied by chronic low-grade inflammation, increased levels of oxidative and nitrosative stress … Continue reading

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A strategy for defining and distinguishing ME & CFS

 Abstract The symptom spectrum of Myalgic Encephalomyelitis (ME) was first detailed in 1959 and later operationalised into a diagnostic protocol (Melvin Ramsey). In 1988 the Holmes case definition coined the term chronic fatigue syndrome (CFS). Fukuda’s Centers for Disease Control … Continue reading

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Inflammation in ME/CFS greater than in depression

A research trial by a multi-national team compared bio-markers in people with ME/CFS, depression and healthy people. Background: Depression is an inflammatory disorder while many authors declare myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) to be a functional disorder. The aim of … Continue reading

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2009 review found CBT/GET ineffective and harmful

Abstract Benign  Myalgic  Encephalomyelitis  (ME)  /  Chronic  Fatigue  Syndrome  (CFS) is  a  debilitating  disease  which,  despite  numerous  biological  abnormalities  has remained highly controversial. Not withstanding  the  medical  pathogenesis  of  ME/CFS,  the  (bio)psychosocial model is adopted by many governmental organizations and … Continue reading

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