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Tag Archives: Post-exertional malaise
Computer simulation explores cause for exercise intolerance in ME/CFS
Research abstract: Post-exertional malaise is commonly observed in patients with myalgic encephalomyelitis/chronic fatigue syndrome, but its mechanism is not yet well understood. A reduced capacity for mitochondrial ATP synthesis is associated with the pathogenesis of CFS and is suspected to … Continue reading
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Tagged ATP, computer simulation, exercise intolerance, mitochondria, Post-exertional malaise
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Fatigue in MS and ME: similarities and differences
Cort Johnson in his blog Health rising asks if the fatigue found in MS and ME is similar or different: Simply looking at the symptoms indicated that MS is primarily a fatiguing disorder, and that MS patients may, in fact, … Continue reading
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Tagged Alan R Light, Cort Johnson, fatigue, gene expression, PEM, Post-exertional malaise, Post-Exertional Relapse Syndrome
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Problems in defining Post exertional malaise
Research abstract: Post-exertional malaise (PEM) is a cardinal symptom of the illnesses referred to as Myalgic Encephalomyelitis (ME), Myalgic Encephalomyelitis/chronic fatigue syndrome (ME/CFS), and chronic fatigue syndrome (CFS). PEM is reported to occur in many of these patients, and with … Continue reading
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Tagged Dr Leonard Jason, Post-exertional malaise
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Could use of stress management skills improve PEM?
Research abstract Chronic Fatigue Syndrome (CFS) is characterized in part by debilitating fatigue typically exacerbated by cognitive and/or physical exertion, referred to as post-exertional malaise (PEM). In a variety of populations, the cortisol awakening response (CAR) has stood out as … Continue reading
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Tagged CAR, Cort Johnson, Cortisol Awakening Response, Daniel L Hall, endocrine dysregulation, HPA axis functioning, PEM, perceived stress management skills, Post-exertional malaise, PSMS
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Prolonged fatigue [CFS] & cytokines post-West Nile Virus infection in USA
Simon McGrath comments on a research paper: Evaluation of Prolonged Fatigue Post–West Nile Virus Infection and Association of Fatigue with Elevated Antiviral and Proinflammatory Cytokines Extract: 31% of the cohort were fatigued at follow-up (44/140) and “Of those with fatigue … Continue reading
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Tagged cytokines, fatigue, PEM, Post-exertional malaise, Simon McGrath, West Nile fever
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Important to distinguish ME (with Post-exertional malaise) from CFS
Abstract Myalgic Encephalomyelitis (ME) was identified as a new clinical entity in 1959 and has been acknowledged as a disease of the central nervous system/neurological disease by the World Health Organisation since 1969. Cognitive impairment, (muscle) weakness, circulatory disturbances, marked … Continue reading
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Tagged diagnosis, Frank Twisk, immune system, PEM, Post-exertional malaise, subgroups, terminology
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Post-exertion malaise in CFS: symptoms & gene expression
Research abstract BACKGROUND A primary complaint of chronic fatigue syndrome (CFS) patients is post-exertion malaise, which is a worsening of symptoms following activities such as exercise. PURPOSE To examine the link between gene expression for metabolite, adrenergic, immune, and glucocorticoid … Continue reading
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Tagged Alan R Light, gene expression, glucocorticoid sensitivity, Jacob D Meyer, PEM, Post-exertional malaise
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