Tag Archives: endocrine dysregulation

Reduction of glucocorticoid receptor function in CFS – no causal link to childhood trauma

Research abstract: Reduction of glucocorticoid receptor function in CFS, by¬†Megan Lynn, Laura Maclachlan, Andreas Finkelmeyer, James Clark, James Locke, Stephen Todryk, Wan-Fai Ng, Julia L Newton, Stuart Watson in Mediators of Inflammation [Preprint¬†April 20, 2018] Glucocorticoid receptor (GR) function may … Continue reading

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Altered neuroendocrine control in adolescent CFS

Research abstract: BACKGROUND: Chronic fatigue syndrome (CFS) is a common and disabling disorder, and a major threat against adolescent health. The pathophysiology is unknown, but alteration of neuroendocrine control systems might be a central element, resulting in attenuation of the … Continue reading

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ME/CFS – not simply chronic fatigue but multisystem disorder

Research abstract: BACKGROUND: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex, chronic illness that is often disabling. This paper introduces the Chronic Fatigue Initiative, which conducted a large multi-center study to more fully characterize ME/CFS and ultimately to describe and … Continue reading

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Could use of stress management skills improve PEM?

Research abstract Chronic Fatigue Syndrome (CFS) is characterized in part by debilitating fatigue typically exacerbated by cognitive and/or physical exertion, referred to as post-exertional malaise (PEM). In a variety of populations, the cortisol awakening response (CAR) has stood out as … Continue reading

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Relationship between insomnia and CFS/ME

Research abstract Fatigue is common in the general population, and is the hallmark of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). Although the occurrence of sleep difficulties is known to be common in subjects with fatigue, research on insomnia in such subjects … Continue reading

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