Tag Archives: HPA axis functioning

Epigenetics study highlights metabolic problems in ME/CFS

Health rising blog post, by Cort Johnson, 30 July 2017: Epigenetics Study Highlights Metabolic Problems in Chronic Fatigue Syndrome (ME/CFS) There was a time that the HPA axis was “it” in chronic fatigue syndrome. More studies have been done on … Continue reading

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Neuroendocrine disorder in CFS

Research abstract: Neuroendocrine disorder in chronic fatigue syndrome, by Slavica TOMIC, Snezana BRKIC, Dajana LENDAK, Daniela MARIC, Milica MEDIC STOJANOSKA, Aleksandra NOVAKOV MIKIC in Turkish Journal of Medical Sciences (2017) 47: sag-1601-110  [Published Online: 17 Dec 2016] Background/aim: Neuroendocrine disorders are … Continue reading

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Epigenetic modifications & glucocorticoid sensitivity in ME/CFS

Research abstract: Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating idiopathic disease characterized by unexplained fatigue that fails to resolve with sufficient rest. Diagnosis is based on a list of symptoms and exclusion of other fatigue-related health conditions. Despite … Continue reading

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Altered neuroendocrine control in adolescent CFS

Research abstract: BACKGROUND: Chronic fatigue syndrome (CFS) is a common and disabling disorder, and a major threat against adolescent health. The pathophysiology is unknown, but alteration of neuroendocrine control systems might be a central element, resulting in attenuation of the … Continue reading

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Altered neuroendocrine control & association to clinical symptoms in adolescent CFS

Research abstract: Background: Chronic fatigue syndrome (CFS) is a common and disabling disorder, and a major threat against adolescent health. The pathophysiology is unknown, but alteration of neuroendocrine control systems might be a central element, resulting in attenuation of the … Continue reading

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Perfectionism & stress in CFS could be due to HPA dysregulation

Article Background: There is increasing evidence that Chronic Fatigue Syndrome (CFS) may reflect a dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis after a prolonged period of hyperactivity due to chronic stress/overload. We and others have hypothesized that chronic stress and subsequent … Continue reading

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COMT gene dysfunction linked to susceptibility to infection in CFS

Research abstract: BACKGROUND: Chronic fatigue syndrome (CFS) is considered as a neuroimmunological disease but the etiology and pathophysiology is poorly understood. Patients suffer from sustained exhaustion, cognitive impairment and an increased sensitivity to pain and sensory stimuli. A subset of … Continue reading

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Could use of stress management skills improve PEM?

Research abstract Chronic Fatigue Syndrome (CFS) is characterized in part by debilitating fatigue typically exacerbated by cognitive and/or physical exertion, referred to as post-exertional malaise (PEM). In a variety of populations, the cortisol awakening response (CAR) has stood out as … Continue reading

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Relationship between insomnia and CFS/ME

Research abstract Fatigue is common in the general population, and is the hallmark of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). Although the occurrence of sleep difficulties is known to be common in subjects with fatigue, research on insomnia in such subjects … Continue reading

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