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Design of PACE trial
Abstract: Background: Clinical trials require large monetary and time commitments and should provide information on both whether and how treatments work. Treatment mechanisms can be studied using mediation analysis, allowing refinement of treatments. Mediation studies often use only single contemporaneous measures of mediator and … Continue reading
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Tagged PACE trial, Prof Peter White, research methods, Trudy Chalder
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Why has the PACE Study’s “Sister Trial” been “Disappeared” and Forgotten?
David Tuller continues his analysis of research about treatments for CFS with an examination of the FINE trial. A summary has been compiled by MEAction. Virology blog: Trial By Error, Continued: Why has the PACE Study’s “Sister Trial”been “Disappeared” and Forgotten? [9 … Continue reading
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Tagged BMJ, British medical Journal, Chalder fatigue scale, FINE trial, Lancet, Medical Research Council, MRC, PACE trial, Prof Alison Wearden, Prof Michael Sharpe, Prof Peter White, Science Media Centre, Tom Kindlon, Trudie Chalder
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PACE trial researchers respond to David Tuller
David Tuller’s three-installment investigation of the PACE trial for CFS, Trial By Error, received much attention in the press. Although the PACE researchers declined David’s efforts to interview them, they subsequently requested the right to reply. Virology blog posted the response of Professors … Continue reading
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Tagged Cort Johnson, David Tuller, PACE trial, Prof Michael Sharpe, Prof Peter White, Trudie Chalder, Virology blog
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White on Pathways to Prevention and PACE
Comment published on 30 June 2015 in the Annals of Internal Medicine on the following article: Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome By PD White, MD, DJ Clauw, MD, JWM van der Meer, MD, R Moss-Morris, PhD, RR Taylor, PhD … Continue reading
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Tagged CBT, cognitive behavioural therapy, GET, graded exercise therapy, JWM van der Meer, NIH, Pathways to prevention workshop, Prof Peter White, R Moss-Morris
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