Research abstract:

Widespread pain is noted in many patients with Chronic Fatigue Syndrome (MECFS), Fibromyalgia (FM) and Temporomandibular disorders (TMD). These conditions usually start as a localized condition and spread to a widespread pain condition with increasing illness duration. The aim of this paper was to assess the changes in biochemistry associated with pin expression and altered renal function.

Forty-seven MECFS patients and age/sex matched controls had: a clinical examination, completed questionnaires, standard serum biochemistry, glucose tolerance tests and serum and urine metabolomes in an observational study.

Increases in pain distribution were associated with reductions in serum essential amino acids, urea, serum sodium and increases in serum glucose and the 24-hour urine volume however the biochemistry was different for each pain area.

Regression modelling revealed potential acetylation and methylation defects in the pain subjects. These findings confirm and extend our earlier findings. These changes appear consistent with repeated minor inflammatory mediated alterations in kidney function resulting in essential amino acid deprivation and inhibition of protein synthesis and genetic translation within tissues.

Widespread pain and altered renal function in ME/CFS patients, by Neil R Mcgregor, Christopher W Armstrong, Paul Raymond Gooley in Researchgate, July 2016