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Variable effects of clonidine treatment in CFS
Research abstract: Clonidine, an α2-adrenergic receptor agonist, decreases circulating norepinephrine and epinephrine, attenuating sympathetic activity. Although catechol-O-methyltransferase (COMT) metabolizes catecholamines, main effectors of sympathetic function, COMT genetic variation effects on clonidine treatment are unknown. Chronic fatigue syndrome (CFS) is hypothesized … Continue reading
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Tagged catechol-O-methyltransferase, clonidine, COMT, KT Hall
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COMT gene dysfunction linked to susceptibility to infection in CFS
Research abstract: BACKGROUND: Chronic fatigue syndrome (CFS) is considered as a neuroimmunological disease but the etiology and pathophysiology is poorly understood. Patients suffer from sustained exhaustion, cognitive impairment and an increased sensitivity to pain and sensory stimuli. A subset of … Continue reading
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Tagged COMT, HPA axis functioning, immune dysregulation, immunoglobulin, RRTI, upper respiratory tract infections
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