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Latest News
- Dysregulated provision of oxidisable substrates to the mitochondria in ME/CFS lymphoblasts
- Sex-based differences in plasma autoantibodies to CNS proteins in Gulf War veterans versus healthy & symptomatic controls
- Sick of the sick role: narratives of what ‘recovery’ means to people with CFS/ME
- Plasma proteomics publication shows disrupted cell-to-cell signaling in ME/CFS
- Open‐label study with the monoamine stabilizer (‐)‐OSU6162 [drug] in ME/CFS
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Tag Archives: COMT
Variable effects of clonidine treatment in CFS
Research abstract: Clonidine, an α2-adrenergic receptor agonist, decreases circulating norepinephrine and epinephrine, attenuating sympathetic activity. Although catechol-O-methyltransferase (COMT) metabolizes catecholamines, main effectors of sympathetic function, COMT genetic variation effects on clonidine treatment are unknown. Chronic fatigue syndrome (CFS) is hypothesized … Continue reading
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Tagged catechol-O-methyltransferase, clonidine, COMT, KT Hall
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COMT gene dysfunction linked to susceptibility to infection in CFS
Research abstract: BACKGROUND: Chronic fatigue syndrome (CFS) is considered as a neuroimmunological disease but the etiology and pathophysiology is poorly understood. Patients suffer from sustained exhaustion, cognitive impairment and an increased sensitivity to pain and sensory stimuli. A subset of … Continue reading
Posted in News
Tagged COMT, HPA axis functioning, immune dysregulation, immunoglobulin, RRTI, upper respiratory tract infections
Comments Off on COMT gene dysfunction linked to susceptibility to infection in CFS