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Latest News
- Dysregulated provision of oxidisable substrates to the mitochondria in ME/CFS lymphoblasts
- Sex-based differences in plasma autoantibodies to CNS proteins in Gulf War veterans versus healthy & symptomatic controls
- Sick of the sick role: narratives of what ‘recovery’ means to people with CFS/ME
- Plasma proteomics publication shows disrupted cell-to-cell signaling in ME/CFS
- Open‐label study with the monoamine stabilizer (‐)‐OSU6162 [drug] in ME/CFS
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Tag Archives: COMT
Variable effects of clonidine treatment in CFS
Research abstract: Clonidine, an α2-adrenergic receptor agonist, decreases circulating norepinephrine and epinephrine, attenuating sympathetic activity. Although catechol-O-methyltransferase (COMT) metabolizes catecholamines, main effectors of sympathetic function, COMT genetic variation effects on clonidine treatment are unknown. Chronic fatigue syndrome (CFS) is hypothesized … Continue reading
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Tagged catechol-O-methyltransferase, clonidine, COMT, KT Hall
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COMT gene dysfunction linked to susceptibility to infection in CFS
Research abstract: BACKGROUND: Chronic fatigue syndrome (CFS) is considered as a neuroimmunological disease but the etiology and pathophysiology is poorly understood. Patients suffer from sustained exhaustion, cognitive impairment and an increased sensitivity to pain and sensory stimuli. A subset of … Continue reading
Posted in News
Tagged COMT, HPA axis functioning, immune dysregulation, immunoglobulin, RRTI, upper respiratory tract infections
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