Tag Archives: immune dysregulation

Treatment avenues in ME/CFS: a split-gender pharmacogenomic study of gene-expression

Treatment avenues in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: a split-gender pharmacogenomic study of gene-expression modules, by Mary G Jeffrey, Lubov Nathanson, Kristina Aenlle, Zachary M Barnes, Mirza Baig, Gordon Broderick, Nancy G Klimas, Mary Ann Fletcher, Travis JA Craddock in Clinical … Continue reading

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Comparison of killer T cells in ME/CFS and MS shows immune dysregulation

Research abstract: Background: CD8+ T cells have putative roles in the regulation of adaptive immune responses during infection. The purpose of this paper is to compare the status of CD8+ T cells in Multiple Sclerosis (MS) and Chronic Fatigue Syndrome/ … Continue reading

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A blood test can distinguish severity CFS/ME subgroups for research

Research abstract: Immunological dysregulation is present in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME), with recent studies also highlighting the importance of examining symptom severity. This research addressed this relationship between CFS/ME severity subgroups, assessing serum immunoglobulins and serum cytokines in severe … Continue reading

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COMT gene dysfunction linked to susceptibility to infection in CFS

Research abstract: BACKGROUND: Chronic fatigue syndrome (CFS) is considered as a neuroimmunological disease but the etiology and pathophysiology is poorly understood. Patients suffer from sustained exhaustion, cognitive impairment and an increased sensitivity to pain and sensory stimuli. A subset of … Continue reading

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Cytokines and CFS

Abstract A major hypothesis for the cause of chronic fatigue syndrome (CFS) is immune dysregulation, thought to reflect upregulated pro-inflammatory cytokines leading to the symptoms characteristic of this illness. Because symptoms worsen with physical exertion or sleep loss, we hypothesized … Continue reading

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