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- Modeling disability: softly making the invisible visible
- Sleep problems in adolescents with CFS: a case-control study nested within a prospective clinical cohort
- Review of the quality control checks performed by current genome-wide & targeted-genome association studies on ME/CFS
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Tag Archives: immune dysregulation
The role of immune responses, focussing on herpes virus specificity & interferon-gamma, in Myocardial Infarction with reperfusion & in CFS
The role of immune responses, focussing on herpes virus specificity and interferon-gamma, in Myocardial Infarction with reperfusion and in Chronic Fatigue Syndrome, by Santosh Murali. Doctoral thesis, Northumbria University, 14 January 2020 Research thesis abstract: Background: Immune responses targeting … Continue reading
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Tagged ep, Herpesvirus, immune dysregulation, immune response, interferon gamma, myocardial infarcation, Santosh Murali, T-cells
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Comparison of killer T cells in ME/CFS and MS shows immune dysregulation
Research abstract: Background: CD8+ T cells have putative roles in the regulation of adaptive immune responses during infection. The purpose of this paper is to compare the status of CD8+ T cells in Multiple Sclerosis (MS) and Chronic Fatigue Syndrome/ … Continue reading
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Tagged CD8+ T cells, immune dysregulation, killer T cells, MS, Multiple Sclerosis
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A blood test can distinguish severity CFS/ME subgroups for research
Research abstract: Immunological dysregulation is present in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME), with recent studies also highlighting the importance of examining symptom severity. This research addressed this relationship between CFS/ME severity subgroups, assessing serum immunoglobulins and serum cytokines in severe … Continue reading
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Tagged blood test, Dr Sonya Marshall-Gradisnik, immune dysregulation, immune profile, Sharni Lee Hardcastle
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COMT gene dysfunction linked to susceptibility to infection in CFS
Research abstract: BACKGROUND: Chronic fatigue syndrome (CFS) is considered as a neuroimmunological disease but the etiology and pathophysiology is poorly understood. Patients suffer from sustained exhaustion, cognitive impairment and an increased sensitivity to pain and sensory stimuli. A subset of … Continue reading
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Tagged COMT, HPA axis functioning, immune dysregulation, immunoglobulin, RRTI, upper respiratory tract infections
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Cytokines and CFS
Abstract A major hypothesis for the cause of chronic fatigue syndrome (CFS) is immune dysregulation, thought to reflect upregulated pro-inflammatory cytokines leading to the symptoms characteristic of this illness. Because symptoms worsen with physical exertion or sleep loss, we hypothesized … Continue reading
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Tagged immune dysregulation, PBLs, peripheral blood lymphocytes, pro-inflammatory cytokines
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