Tag Archives: immune dysregulation
Research review: What causes ME/CFS: The role of the dysfunctional immune system & viral infections
Is the immune dysregulation hypothesis proven? A European team led by Dr Amolak Bansal review a number of areas of research into ME/CFS before concluding: “After over 20 year of attempting to identify specific immune defects and infectious agents … Continue reading
Research: Pathomechanisms & possible interventions in ME/CFS
Pathomechanisms and possible interventions in myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS), by Øystein Fluge, Karl J. Tronstad, and Olav Mella in J Clin Invest. 2021;131(14):e150377 [doi.org/10.1172/JCI150377] July 15, 2021 Research abstract: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease with … Continue reading
The role of immune responses, focussing on herpes virus specificity & interferon-gamma, in Myocardial Infarction with reperfusion & in CFS
The role of immune responses, focussing on herpes virus specificity and interferon-gamma, in Myocardial Infarction with reperfusion and in Chronic Fatigue Syndrome, by Santosh Murali. Doctoral thesis, Northumbria University, 14 January 2020 Research thesis abstract: Background: Immune responses targeting … Continue reading
Comparison of killer T cells in ME/CFS and MS shows immune dysregulation
Research abstract: Background: CD8+ T cells have putative roles in the regulation of adaptive immune responses during infection. The purpose of this paper is to compare the status of CD8+ T cells in Multiple Sclerosis (MS) and Chronic Fatigue Syndrome/ … Continue reading
A blood test can distinguish severity CFS/ME subgroups for research
Research abstract: Immunological dysregulation is present in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME), with recent studies also highlighting the importance of examining symptom severity. This research addressed this relationship between CFS/ME severity subgroups, assessing serum immunoglobulins and serum cytokines in severe … Continue reading
COMT gene dysfunction linked to susceptibility to infection in CFS
Research abstract: BACKGROUND: Chronic fatigue syndrome (CFS) is considered as a neuroimmunological disease but the etiology and pathophysiology is poorly understood. Patients suffer from sustained exhaustion, cognitive impairment and an increased sensitivity to pain and sensory stimuli. A subset of … Continue reading
Cytokines and CFS
Abstract A major hypothesis for the cause of chronic fatigue syndrome (CFS) is immune dysregulation, thought to reflect upregulated pro-inflammatory cytokines leading to the symptoms characteristic of this illness. Because symptoms worsen with physical exertion or sleep loss, we hypothesized … Continue reading
