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B-cell function in patients with ME/CFS
Research summary: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a heterogeneous condition of unknown etiology characterized by multiple symptoms including fatigue, post-exertional malaise and cognitive impairment, lasting for at least 6 months. Recently, two clinical trials of B-cell depletion therapy with rituximab (anti-CD20) reported convincing … Continue reading
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Tagged B cells, flow cytometry, rituximab
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To future GPs – psychosomatic should not be the default suspicion re ME/CFS
Time to swot up on chronic fatigue – Future general practitioners need to be made aware that “psychosomatic” should not be the default suspicion, by Michael Brooks in the New Statesman, Nov 12 2015 Around 250,000 people in the UK suffer from … Continue reading
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Tagged CBT, cognitive behavioural therapy, GET, Graded exercied, graded exercise therapy, ME Association, Michael Brooks, New Statesman, PACE trial, psychosomatic, rituximab
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Cancer doctor Dagfinn Øgreid has treated ME patients with rituximab
Blog article: Offers private ME treatment with cancer drugs – scientists react, by Anne Grete Storvik, Nov 23 2015 in Dagensmedicin [ translated by Google translate] A private clinic in Sandnes offers treatment for ME with the cancer drug rituximab. Patients pay … Continue reading
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Tagged autoimmune disorders, Dr Dagfinn Øgreid, Dr Oystein Fluge, immunomodulatory drug, Norway, Prof Olav Mella, rituximab
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UK rituximab trial fundraising total almost reached
Invest in ME has announced the latest fundraising total for the rituximab/B-cell research, which is a great boost as the research team at UCL are about to visit and discuss the subject with Dr Fluge and Professor Mella in Haukeland University Hospital, … Continue reading
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Tagged B-cell, Dr Oystein Fluge, IiME, Invest in ME, Prof Olav Mella, rituximab, UCL, University College London
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Elevated autoantibodies found in CFS subgroup
Research highlights: β adrenergic and muscarinic acetylcholine receptor autoantibodies are elevated in a subset of patients with Chronic Fatigue Syndrome (CFS). Elevated autoantibodies in CFS correlate with elevated IgG1-3 subclass levels, thyreoperoxidase and ANA antibodies and T cell activation. In … Continue reading
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Tagged autoantibodies, autoimmune disorders, Dr Oystein Fluge, Prof Olav Mella, Receptors, rituximab, subgroup, T-cell
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Rituximab leads to B-cell depletion and remission in ME/CFS
Research abstract: Background: Myalgic Encephalopathy/Chronic Fatigue Syndrome (ME/CFS) is a disease of unknown etiology. We previously reported a pilot case series followed by a small, randomized, placebo-controlled phase II study, suggesting that B-cell depletion using the monoclonal anti-CD20 antibody rituximab … Continue reading
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Tagged antibodies, B-cell, Dr Olav Mella, Dr Oystein Fluge, New Scientist, rituximab
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Rituximab interviews
Two Norwegian scientists, Øystein Fluge and Olav Mella, who have been researching the effects of an anti-lymphoma drug called Rituximab on people with ME/CFS, talked about their work on the BBC Radio Cambridgeshire programme ‘Naked Scientists’ on Sunday, 22 March. … Continue reading
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Tagged autoimmune disorders, BBC radio, blood vessels, cardiopulmonary tests, Cyclophosphamide, Dr Olav Mella, Dr Oystein Fluge, endothelial dysfunction, exercise tests, gastrointestinal disorder, gene expression, immunomodulatory drug, rituximab, Teresa Grøtan
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Anti-inflammatory drugs and CFS/ME
Richard N. Podell M.D., MPH discusses the implications of Japanese research which found inflammation in the brain on the prohealth website: For most people with Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis (CFS/ME) central nervous system function is abnormal. However, we don’t understand the … Continue reading
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Tagged anti-inflammatory drugs, brain, CT scan, herbs, immune activation, inflammation, LDN, low dose naltrexone, MRI, PET, rituximab, tetracycline
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Norwegian Rituximab trial update
The Norwegian multicenter Rituximab study begins The long-awaited Norwegian phase III study of Rituximab as a treatment for ME/CFS is now getting off the ground. The study is led by the oncologists Prof Olav Mella and Dr Øystein Fluge at … Continue reading
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Tagged Dr Jo Cambridge, Dr Oystein Fluge, Norway, Prof Jonathan Edwards, Prof Olav Mella, rituximab
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Immunostimulants – an alternative treatment to rituximab
Abstract Chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME) has long been associated with the presence of infectious agents, but no single pathogen has been reliably identified in all patients with the disease. Recent studies using metagenomic techniques have demonstrated the presence … Continue reading
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Tagged immunostimulation, immunosuppressants, olmesar tan medoxomil, rituximab
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