Tag Archives: immune activation

Cellular immune function in ME/CFS: increased MAIT cell frequency

Cellular immune function in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), by Jacqueline M Cliff, Elizabeth C King, Ji-Sook Lee, Nuno Sepulveda, Asia-Sofia Wolf, Caroline Kingdon, Erinna Bowman, Hazel M. Dockrell, Luis C. Nacul, Eliana Lacerda, Eleanor Riley in Front. Immunol., 16 April … Continue reading

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Peterson’s atypical subset opens new view of ME/CFS

Simmaron research blog post, by Cort Johnson, 5 April 2017: Peterson’s Atypical Subset Opens New View of ME/CFS in Columbia/Simmaron Publication “We now have biological evidence that the triggers for ME/CFS may involve distinct pathways to disease, or, in some … Continue reading

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The role of inflammation & over active immune system in depression

BBC news report, by James Gallagher, Rachael Buchanan & Andrew Luck-Baker, 24 August 2016: Depression: A revolution in treatment? The Inflamed Mind, BBC Radio 4 It’s not very often we get to talk about a revolution in understanding and treating depression … Continue reading

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Intestinal cell damage & systemic immune activation in people with sensitivity to wheat

Research abstract: Objective:  Wheat gluten and related proteins can trigger an autoimmune enteropathy, known as coeliac disease, in people with genetic susceptibility. However, some individuals experience a range of symptoms in response to wheat ingestion, without the characteristic serological or … Continue reading

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Dysfunctional low affinity antibodies leads to gut & immune problems in ME/CFS

Research abstract: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a heterogeneous illness characterized by a number of comorbid conditions; gastrointestinal (GI) dysregulation make up one subgroup of this disease. IgA is the most abundant antibody isotype found in mucosal secretions including … Continue reading

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Indicator of CFS found in gut bacteria

Cornell Chronicle blog post by Krishna Ramanujan, 24 June 2016: Indicator of chronic fatigue syndrome found in gut bacteria Physicians have been mystified by chronic fatigue syndrome, a condition where normal exertion leads to debilitating fatigue that isn’t alleviated by rest. … Continue reading

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Are ME/CFS and FM immune exhaustion disorders?

Are Chronic Fatigue Syndrome (ME/CFS) and Fibromyalgia Immune Exhaustion Disorders?, by Cort Johnson 21 March 2016 When we think of immune problems we often think of the immune system going berserk and attacking healthy cells but another kind of immune … Continue reading

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Immune activation in the central nervous system of ME/CFS found by cytokine network analysis of cerebrospinal fluid

Research abstract: Myalgic encephalomyelitis/chronic fatigue syndrome is an unexplained debilitating disorder that is frequently associated with cognitive and motor dysfunction. We analyzed cerebrospinal fluid from 32 cases, 40 subjects with multiple sclerosis and 19 normal subjects frequency-matched for age and … Continue reading

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Central nervous system clues found for cognitive dysfunction in CFS

Research abstract: Myalgic encephalomyelitis/chronic fatigue syndrome is an unexplained debilitating disorder that is frequently associated with cognitive and motor dysfunction. We analyzed cerebrospinal fluid from 32 cases, 40 subjects with multiple sclerosis and 19 normal subjects frequency-matched for age and … Continue reading

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Immune changes in peripheral blood in CFS

Book chapter abstract: Chronic Fatigue Syndrome (CFS) is recognized by the WHO as an alternative name  for Myalgic Encephalomyelitis, which has been classified as a disease of the central nervous system since 1969. The concept that chronic microbial infection drives … Continue reading

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